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    mapk10 mitogen-activated protein kinase 10 [ Danio rerio (zebrafish) ]

    Gene ID: 569698, updated on 28-Oct-2024

    Summary

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    Official Symbol
    mapk10provided by ZNC
    Official Full Name
    mitogen-activated protein kinase 10provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051120-117
    See related
    Ensembl:ENSDARG00000102730 AllianceGenome:ZFIN:ZDB-GENE-051120-117
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:123234
    Summary
    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. In mammals, this kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
    Orthologs
    human mouse all
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    Genomic context

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    See mapk10 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (9576173..9722997)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (9483018..9624665)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene SDA1 domain containing 1 Neighboring gene protein tyrosine phosphatase non-receptor type 13 Neighboring gene Rho GTPase activating protein 24 Neighboring gene endothelial cell-specific molecule 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A Novel Zebrafish ret Heterozygous Model of Hirschsprung Disease Identifies a Functional Role for mapk10 as a Modifier of Enteric Nervous System Phenotype Severity. Heanue TA, et al. PLoS Genet, 2016 Nov. PMID 27902697, Free PMC Article
    2. JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes. Drerup CM, et al. PLoS Genet, 2013. PMID 23468645, Free PMC Article
    3. The gsdf gene locus harbors evolutionary conserved and clustered genes preferentially expressed in fish previtellogenic oocytes. Gautier A, et al. Gene, 2011 Feb 1. PMID 21047546
    4. Reduction in Toxicity of Nano-Ag-Polyvinyl-pyrrolidone Using Hydra Proteins and Peptides during Zebrafish Embryogenesis. Kim SS, et al. Nanomaterials (Basel), 2019 Aug 27. PMID 31462001, Free PMC Article
    5. Optimal combination of anti-inflammatory components from Chinese medicinal formula Liang-Ge-San. Lu Z, et al. J Ethnopharmacol, 2021 Apr 6. PMID 33359185

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123234

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within enteric nervous system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within enteric nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 10
    Names
    jnk3
    NP_001032790.1
    NP_001305247.1
    NP_001305248.1
    NP_001305250.1
    XP_005161528.1
    XP_005161530.1
    XP_005161531.1
    XP_009293442.1
    XP_009293445.1
    XP_017208303.1
    XP_017208304.1
    XP_017208305.1
    XP_017208306.1
    XP_021324568.1
    XP_068072023.1
    XP_068072024.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037701.2 → NP_001032790.1  mitogen-activated protein kinase 10 isoform 2

      See identical proteins and their annotated locations for NP_001032790.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon, which causes a frameshift compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC109420, BC139642, EH577174, EH579484
      UniProtKB/TrEMBL
      A0A8M1N8E9, A4QP40, Q32LV0
      Related
      ENSDARP00000139912.1, ENSDART00000162834.2
      Conserved Domains (2) summary
      smart00220
      Location:64 → 359
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:63 → 406
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    2. NM_001318318.1 → NP_001305247.1  mitogen-activated protein kinase 10 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).
      Source sequence(s)
      BC109420, BC139642, EH577174, EH579484
      UniProtKB/TrEMBL
      A0A0R4IKK9, A0A8M1P821, A4QP40
      Related
      ENSDARP00000134326.2, ENSDART00000160711.2
      Conserved Domains (2) summary
      smart00220
      Location:64 → 359
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:63 → 406
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    3. NM_001318319.1 → NP_001305248.1  mitogen-activated protein kinase 10 isoform 1x

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      BC109420, BC139642, EH577174, EH579484
      UniProtKB/TrEMBL
      A0A8M1P270
      Conserved Domains (2) summary
      smart00220
      Location:64 → 359
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:63 → 406
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    4. NM_001318321.1 → NP_001305250.1  mitogen-activated protein kinase 10 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate acceptor splice site in the 5' region (which results in translation initiation from an in-frame, downstream start codon), lacks an in-frame coding exon, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. The resulting isoform (3) has a shorter N-terminus, lacks an 8 aa internal protein segment, and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC109420, BC139642, EH577174, EH579484
      UniProtKB/TrEMBL
      A0A0R4I9H8, A0A8M1P8D2, A4QP40
      Related
      ENSDARP00000129891.1, ENSDART00000159899.2
      Conserved Domains (2) summary
      smart00220
      Location:26 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:25 → 360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      9576173..9722997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215922.1 → XP_068072023.1  mitogen-activated protein kinase 10 isoform X5

    2. XM_068215923.1 → XP_068072024.1  mitogen-activated protein kinase 10 isoform X5

    3. XM_017352815.3 → XP_017208304.1  mitogen-activated protein kinase 10 isoform X5

      UniProtKB/TrEMBL
      A0A8M6Z3P4, A4QP40
      Conserved Domains (2) summary
      smart00220
      Location:26 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:25 → 368
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    4. XM_017352816.3 → XP_017208305.1  mitogen-activated protein kinase 10 isoform X5

      UniProtKB/TrEMBL
      A0A8M6Z3P4, A4QP40
      Conserved Domains (2) summary
      smart00220
      Location:26 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:25 → 368
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    5. XM_017352814.3 → XP_017208303.1  mitogen-activated protein kinase 10 isoform X3

      UniProtKB/TrEMBL
      A0A8M6YV43, A4QP40

    6. XM_005161471.5 → XP_005161528.1  mitogen-activated protein kinase 10 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B8D5
      Conserved Domains (2) summary
      smart00220
      Location:67 → 362
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:66 → 409
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    7. XM_005161473.5 → XP_005161530.1  mitogen-activated protein kinase 10 isoform X4

      UniProtKB/TrEMBL
      A0A8M2B8C2, A4QP40
      Conserved Domains (2) summary
      smart00220
      Location:67 → 362
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:66 → 401
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    8. XM_009295167.4 → XP_009293442.1  mitogen-activated protein kinase 10 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AWM8
      Conserved Domains (2) summary
      smart00220
      Location:67 → 362
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:66 → 409
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    9. XM_005161474.5 → XP_005161531.1  mitogen-activated protein kinase 10 isoform X7

      UniProtKB/TrEMBL
      A0A0R4IB91, A0A8M2B8F3, A4QP40
      Related
      ENSDARP00000131673.1, ENSDART00000161289.2
      Conserved Domains (1) summary
      cd07850
      Location:66 → 409
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    10. XM_009295170.4 → XP_009293445.1  mitogen-activated protein kinase 10 isoform X6

      UniProtKB/TrEMBL
      A0A8M6YUI1, A4QP40
      Conserved Domains (1) summary
      cd07850
      Location:66 → 409
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    11. XM_021468893.2 → XP_021324568.1  mitogen-activated protein kinase 10 isoform X8

      UniProtKB/TrEMBL
      A0A8M9PCS4, A4QP40
      Conserved Domains (1) summary
      cd07850
      Location:66 → 401
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    12. XM_017352817.3 → XP_017208306.1  mitogen-activated protein kinase 10 isoform X6

      UniProtKB/TrEMBL
      A0A8M6YUI1, A4QP40
      Conserved Domains (1) summary
      cd07850
      Location:66 → 409
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    RNA

    1. XR_011007969.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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