Adap2 ArfGAP with dual PH domains 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adap2provided by RGD
Official Full Name: ArfGAP with dual PH domains 2provided by RGD
Primary source: RGD:708487
See related: AllianceGenome:RGD:708487
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Centa2
Summary: Enables phosphatidylinositol binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in heart development. Predicted to act upstream of or within inositol lipid-mediated signaling. Located in membrane and mitochondrial envelope. Orthologous to human ADAP2 (ArfGAP with dual PH domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 106.7), Spleen (RPKM 80.2) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10q25

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (65635891..65665019)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (65138006..65166147)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (67494851..67527582)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results describe the cloning, expression and characterisation of centaurin-alpha2 from a rat adipocyte cDNA library.
Title: Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

AU026537 (e-PCR)
- UniSTS:114183

Centa2 (e-PCR), detects polymorphism
- UniSTS:498226

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables inositol 1,3,4,5 tetrakisphosphate binding	ISO Inferred from Sequence Orthology more info
enables inositol 1,3,4,5 tetrakisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: arf-GAP with dual PH domain-containing protein 2

Names: Centaurin-alpha2 protein; centaurin-alpha-2; cnt-a2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020101.2 → NP_064486.1 arf-GAP with dual PH domain-containing protein 2

See identical proteins and their annotated locations for NP_064486.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q9JK15

UniProtKB/TrEMBL

A6HHA5

Conserved Domains (4) summary

cd01251
Location:254 → 361

PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2

cd13252
Location:132 → 240

PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1

pfam00169
Location:257 → 360

PH; PH domain

pfam01412
Location:9 → 122

ArfGap; Putative GTPase activating protein for Arf

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

65635891..65665019

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269737.1 → XP_063125807.1 arf-GAP with dual PH domain-containing protein 2 isoform X1
XM_039086713.2 → XP_038942641.1 arf-GAP with dual PH domain-containing protein 2 isoform X2

UniProtKB/TrEMBL

D3ZQG5

Conserved Domains (3) summary

cd01251
Location:278 → 385

PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2

cd13252
Location:156 → 264

PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1

cl28907
Location:4 → 141

ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
XM_063269738.1 → XP_063125808.1 arf-GAP with dual PH domain-containing protein 2 isoform X3
XM_063269739.1 → XP_063125809.1 arf-GAP with dual PH domain-containing protein 2 isoform X4