Ramp3 receptor activity modifying protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ramp3provided by RGD
Official Full Name: receptor activity modifying protein 3provided by RGD
Primary source: RGD:61873
See related: AllianceGenome:RGD:61873
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables coreceptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Predicted to be located in lysosome and plasma membrane. Predicted to be part of adrenomedullin receptor complex and amylin receptor complex 3. Predicted to be active in cell surface. Orthologous to human RAMP3 (receptor activity modifying protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 118.9), Uterus (RPKM 104.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (85741314..85758813)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (81527404..81544905)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (86922223..86939722)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased expression of IMD and all its receptor components (CRLR, RAMP1, RAMP2, and RAMP3) were displayed within the aorta of rats with Hypercholesterolemia.
Title: Hypercholesterolemia Up-Regulates the Expression of Intermedin and Its Receptor Components in the Aorta of Rats via Inducing the Oxidative Stress.
ADM peptide concentration exhibited a spatio-temporal pattern in the rat female reproductive system during gestation and this suggests that ADM may play important roles in gestation.
Title: Coexpression of adrenomedullin and its receptor component proteins in the reproductive system of the rat during gestation.
L-NAME elicited hypertrophic phenotype in cardiomyocytes accompanied by altered expression of adrenomedullin and RAMP2 and RAMP3. Adrenomedullin is due to impaired nitric oxide synthesis, whereas the phenotypic changes are due to pressure overload.
Title: Upregulation of adrenomedullin and its receptor components during cardiomyocyte hypertrophy induced by chronic inhibition of nitric oxide synthesis in rats.
Data suggest that intracardiac adrenomedullin and calcitonin receptor-like receptor/receptor activity-modifying proteins (RAMP2 and RAMP3) complexes, are upregulated in volume overload-induced cardiac hypertrophy.
Title: Upregulation of intracardiac adrenomedullin and its receptor system in rats with volume overload-induced cardiac hypertrophy.
induction of RAMP2 and RAMP3 contributes to the increased responsiveness to adrenomedullin in failing cardiomyocytes
Title: RAMP2 and RAMP3 mRNA levels are increased in failing rat cardiomyocytes and associated with increased responsiveness to adrenomedullin.
Up-regulation of RAMP1 and RAMP3 mRNAs detected in myocarium of rats with chronic heart failure
Title: Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure.
Results showed that mRNA expression of the receptor components was significantly higher in pregnant compared to nonpregnant rats
Title: Changes in the expression of calcitonin receptor-like receptor, receptor activity-modifying protein (RAMP) 1, RAMP2, and RAMP3 in rat uterus during pregnancy, labor, and by steroid hormone treatments.
By using in situ hybridization, the codistribution of CT((a))/CT((b)) with RAMP1-3 and c-fos was mapped in CVOs of rats.
Title: Peripheral amylin activates circumventricular organs expressing calcitonin receptor a/b subtypes and receptor-activity modifying proteins in the rat.
mRNA differential display analysis identified two genes, viz. BAALC and RAMP3, whose expression is altered in primary astrocytes treated with differentiation inducers.
Title: Induction of BAALC and down regulation of RAMP3 in astrocytes treated with differentiation inducers.
Results suggest that liver cirrhosis increases mRNA expressions of adrenomedullin (AM), calcitonin-like-receptor and receptor activity modifying proteins 1, 2 and 3 and that the increase in AM gene expression precedes the development of cirrhosis.
Title: The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	NAS Non-traceable Author Statement more info	PubMed
enables adrenomedullin receptor activity	ISO Inferred from Sequence Orthology more info
enables amylin receptor activity	ISO Inferred from Sequence Orthology more info
enables coreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables coreceptor activity	IDA Inferred from Direct Assay more info	PubMed
enables coreceptor activity	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway involved in heart process	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway involved in heart process	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adrenomedullin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in amylin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to estradiol stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to estradiol stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cross-receptor inhibition within G protein-coupled receptor heterodimer	IEA Inferred from Electronic Annotation more info
involved_in cross-receptor inhibition within G protein-coupled receptor heterodimer	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cAMP/PKA signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cAMP/PKA signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in response to amyloid-beta	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of adrenomedullin receptor complex	ISO Inferred from Sequence Orthology more info
part_of amylin receptor complex 3	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor activity-modifying protein 3

Names: receptor (G protein-coupled) activity modifying protein 3; receptor (calcitonin) activity modifying protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020100.2 → NP_064485.2 receptor activity-modifying protein 3 precursor

See identical proteins and their annotated locations for NP_064485.2

Status: PROVISIONAL

Source sequence(s)

AF181552

UniProtKB/Swiss-Prot

Q9JJ73

UniProtKB/TrEMBL

A6IKW0, Q9JMD8

Conserved Domains (1) summary

pfam04901
Location:37 → 144

RAMP; Receptor activity modifying family