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    Extl3 exostosin-like glycosyltransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56819, updated on 2-Nov-2024

    Summary

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    Symbol
    Extl3provided by RGD
    Full Name
    exostosin-like glycosyltransferase 3provided by RGD
    Primary source
    RGD:62065
    See related
    EnsemblRapid:ENSRNOG00000013581 AllianceGenome:RGD:62065
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Regr
    Summary
    Predicted to enable glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; magnesium ion binding activity; and protein-hormone receptor activity. Involved in positive regulation of cell growth. Predicted to be located in endoplasmic reticulum. Predicted to be active in Golgi apparatus and plasma membrane. Orthologous to human EXTL3 (exostosin like glycosyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 145.2), Muscle (RPKM 95.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Extl3 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (43469293..43559760, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (39294033..39384086, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (48420419..48465171, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene homeobox containing 1 Neighboring gene high mobility group nucleosomal binding domain 4, pseudogene 7 Neighboring gene integrator complex subunit 9 Neighboring gene uncharacterized LOC134482133 Neighboring gene H/ACA ribonucleoprotein complex subunit 3-like Neighboring gene frizzled class receptor 3 Neighboring gene F-box protein 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Localization of Reg receptor in rat fundic mucosa. Kazumori H, et al. J Lab Clin Med, 2002 Feb. PMID 11919548
    2. Mutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome. Oud MM, et al. Am J Hum Genet, 2017 Feb 2. PMID 28132690, Free PMC Article
    3. Pancreatic regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis. Bluth MH, et al. World J Gastroenterol, 2006 Jul 28. PMID 16874863, Free PMC Article
    4. Identification of a receptor for reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor. Kobayashi S, et al. J Biol Chem, 2000 Apr 14. PMID 10753861
    5. EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay. Volpi S, et al. J Exp Med, 2017 Mar 6. PMID 28148688, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regenerating islet-derived 1alpha (Reg-1alpha) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor.
      Title: Regenerating islet-derived 1α (Reg-1α) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor.
    2. localization in fundic mucosa
      Title: Localization of Reg receptor in rat fundic mucosa.
    3. Acute pancreatitis results in increased tissue reg I protein levels in the pancreas, as well as a threefold induction of reg I receptor. Induction of reg I and its receptor may be important for recovery from acute pancreatitis.
      Title: Pancreatic regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inflammatory response to wounding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of detection of glucose ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    exostosin-like 3
    Names
    Reg receptor
    exostoses (multiple)-like 3
    exostoses-like 3
    exostosin-like 3-like
    NP_064482.1
    XP_006252268.1
    XP_038949546.1
    XP_038949547.1
    XP_038949548.1
    XP_038949550.1
    XP_038949551.1
    XP_063130666.1
    XP_063130667.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431349.1 → NP_001418278.1  exostosin-like 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      F7F308, Q9JMA8

    2. NM_001431350.1 → NP_001418279.1  exostosin-like 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      F7F308, Q9JMA8

    3. NM_001431351.1 → NP_001418280.1  exostosin-like 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      F7F308, Q9JMA8

    4. NM_001431352.1 → NP_001418281.1  exostosin-like 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      F7F308, Q9JMA8

    5. NM_001431353.1 → NP_001418282.1  exostosin-like 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      F7F308, Q9JMA8

    6. NM_001431354.1 → NP_001418283.1  exostosin-like 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      F7F308, Q9JMA8

    7. NM_001431355.1 → NP_001418284.1  exostosin-like 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      F7F308, Q9JMA8

    8. NM_020097.3 → NP_064482.1  exostosin-like 3

      See identical proteins and their annotated locations for NP_064482.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2K6F4, F7F308, Q9JMA8
      Related
      ENSRNOP00000073791.3, ENSRNOT00000077197.3
      Conserved Domains (3) summary
      COG1196
      Location:86 → 145
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam03016
      Location:190 → 500
      Exostosin; Exostosin family
      pfam09258
      Location:663 → 900
      Glyco_transf_64; Glycosyl transferase family 64 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      43469293..43559760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093619.2 → XP_038949547.1  exostosin-like 3 isoform X1

      Conserved Domains (3) summary
      COG1196
      Location:86 → 145
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam03016
      Location:190 → 500
      Exostosin; Exostosin family
      pfam09258
      Location:663 → 900
      Glyco_transf_64; Glycosyl transferase family 64 domain

    2. XM_039093622.2 → XP_038949550.1  exostosin-like 3 isoform X1

      Conserved Domains (3) summary
      COG1196
      Location:86 → 145
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam03016
      Location:190 → 500
      Exostosin; Exostosin family
      pfam09258
      Location:663 → 900
      Glyco_transf_64; Glycosyl transferase family 64 domain

    3. XM_039093618.2 → XP_038949546.1  exostosin-like 3 isoform X1

      Conserved Domains (3) summary
      COG1196
      Location:86 → 145
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam03016
      Location:190 → 500
      Exostosin; Exostosin family
      pfam09258
      Location:663 → 900
      Glyco_transf_64; Glycosyl transferase family 64 domain

    4. XM_039093623.2 → XP_038949551.1  exostosin-like 3 isoform X1

      Conserved Domains (3) summary
      COG1196
      Location:86 → 145
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam03016
      Location:190 → 500
      Exostosin; Exostosin family
      pfam09258
      Location:663 → 900
      Glyco_transf_64; Glycosyl transferase family 64 domain

    5. XM_063274597.1 → XP_063130667.1  exostosin-like 3 isoform X1

    6. XM_039093620.2 → XP_038949548.1  exostosin-like 3 isoform X1

      Conserved Domains (3) summary
      COG1196
      Location:86 → 145
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam03016
      Location:190 → 500
      Exostosin; Exostosin family
      pfam09258
      Location:663 → 900
      Glyco_transf_64; Glycosyl transferase family 64 domain

    7. XM_063274596.1 → XP_063130666.1  exostosin-like 3 isoform X1

    8. XM_006252206.5 → XP_006252268.1  exostosin-like 3 isoform X1

      See identical proteins and their annotated locations for XP_006252268.1

      UniProtKB/TrEMBL
      A0A0G2K6F4, F7F308, Q9JMA8
      Conserved Domains (3) summary
      COG1196
      Location:86 → 145
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam03016
      Location:190 → 500
      Exostosin; Exostosin family
      pfam09258
      Location:663 → 900
      Glyco_transf_64; Glycosyl transferase family 64 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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