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    dpp6b dipeptidyl-peptidase 6b [ Danio rerio (zebrafish) ]

    Gene ID: 566832, updated on 12-Sep-2024

    Summary

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    Official Symbol
    dpp6bprovided by ZNC
    Official Full Name
    dipeptidyl-peptidase 6bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070705-88
    See related
    Ensembl:ENSDARG00000024744 AllianceGenome:ZFIN:ZDB-GENE-070705-88
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dpp6; si:ch211-198f16.1
    Summary
    Predicted to enable serine-type peptidase activity. Predicted to be involved in regulation of potassium ion transmembrane transport. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; autosomal dominant non-syndromic intellectual disability 33; and spinal muscular atrophy. Orthologous to human DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See dpp6b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (12406712..12704026, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (12723926..13021220, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene phosphoribosyl transferase domain containing 1b Neighboring gene Rho GTPase activating protein 21b Neighboring gene lysine (K)-specific methyltransferase 2Cb Neighboring gene protein kinase, AMP-activated, gamma 2 non-catalytic subunit b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dipeptidyl aminopeptidase-like protein 6b; dipeptidyl-peptidase 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115122.1 → NP_001108594.1  dipeptidyl-peptidase 6

      Status: PROVISIONAL

      Source sequence(s)
      BX005226, BX547997, CT030720
      UniProtKB/TrEMBL
      A0A8M1NHZ0
      Conserved Domains (3) summary
      COG1506
      Location:433 → 850
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00930
      Location:195 → 560
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:642 → 850
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      12406712..12704026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224691.1 → XP_068080792.1  dipeptidyl aminopeptidase-like protein 6b isoform X3

      Related
      ENSDARP00000154358.1, ENSDART00000186781.1

    2. XM_068224689.1 → XP_068080790.1  dipeptidyl aminopeptidase-like protein 6b isoform X2

    3. XM_005163289.4 → XP_005163346.1  dipeptidyl aminopeptidase-like protein 6b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BAG6, E7F5R8
      Related
      ENSDARP00000028871.5, ENSDART00000037848.7
      Conserved Domains (3) summary
      COG1506
      Location:422 → 839
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00930
      Location:184 → 549
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:631 → 839
      Abhydrolase; alpha/beta hydrolases

    4. XM_005163291.5 → XP_005163348.1  dipeptidyl aminopeptidase-like protein 6b isoform X5

      UniProtKB/TrEMBL
      A0A8M2BAP0
      Conserved Domains (3) summary
      COG1506
      Location:372 → 789
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00930
      Location:134 → 499
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:581 → 789
      Abhydrolase; alpha/beta hydrolases

    5. XM_005163290.5 → XP_005163347.1  dipeptidyl aminopeptidase-like protein 6b isoform X4

      UniProtKB/TrEMBL
      A0A8M2BAB2
      Conserved Domains (3) summary
      COG1506
      Location:375 → 792
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00930
      Location:137 → 502
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:584 → 792
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version

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