fstb follistatin b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fstbprovided by ZNC
Official Full Name: follistatin bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031118-139
See related: Ensembl:ENSDARG00000057992 AllianceGenome:ZFIN:ZDB-GENE-031118-139
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fst2; fstl; zeh1606; hm:zeh1606; zgc:171342
Summary: Predicted to enable activin binding activity. Predicted to be involved in cell differentiation; negative regulation of activin receptor signaling pathway; and regulation of BMP signaling pathway. Predicted to be active in extracellular space. Is expressed in several structures, including brain; heart; integument; pharyngeal arch 3-7 skeleton; and somite. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (follistatin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (8968206..8976823)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (9134647..9143264)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

While Chordin is the main player of the D/V axis, the structures remaining in the chd mutant in both mesodermal and ectodermal layers) result from the anti-Bmp activity carried by Nog1 and Fstl2 at blastula and gastrula stages.
Title: Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables activin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: follistatin b

Names: follistatin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039631.1 → NP_001034720.1 follistatin b isoform 1 precursor

See identical proteins and their annotated locations for NP_001034720.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

DQ317969

UniProtKB/TrEMBL

A0A8M1N8D5, Q2PMI4

Related

ENSDARP00000075218.5, ENSDART00000080772.6

Conserved Domains (2) summary

smart00280
Location:192 → 239

KAZAL; Kazal type serine protease inhibitors

cl00097
Location:95 → 150

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
NM_001109831.1 → NP_001103301.1 follistatin b isoform 2 precursor

See identical proteins and their annotated locations for NP_001103301.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (2) extends through a splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

BC151865

UniProtKB/TrEMBL

A7MBP8

Related

ENSDARP00000099856.3, ENSDART00000110443.5

Conserved Domains (2) summary

smart00280
Location:192 → 239

KAZAL; Kazal type serine protease inhibitors

cl00097
Location:95 → 150

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...