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    wwp2 WW domain containing E3 ubiquitin protein ligase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 564527, updated on 18-Sep-2024

    Summary

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    Official Symbol
    wwp2provided by ZNC
    Official Full Name
    WW domain containing E3 ubiquitin protein ligase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000607-82
    See related
    Ensembl:ENSDARG00000061345 AllianceGenome:ZFIN:ZDB-GENE-000607-82
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    id:ibd1121; wu:fo87e10; zgc:154036
    Summary
    Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within roof of mouth development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in brain; germ ring; head; pectoral fin bud; and tail bud. Orthologous to human WWP2 (WW domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See wwp2 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (34749179..34804029)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (34243127..34299071)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene nucleoporin 160 Neighboring gene fibroblast growth factor receptor substrate 2b Neighboring gene microRNA 140 Neighboring gene adenosine deaminase tRNA specific 1 Neighboring gene GABA(A) receptor-associated protein like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanisms of the cartilage-specific microRNA-140 in osteoarthritis. Zhang R, et al. Inflamm Res, 2013 Oct. PMID 23942573
    2. Unique roles of microRNA140 and its host gene WWP2 in cartilage biology. Nakamura Y, et al. J Musculoskelet Neuronal Interact, 2008 Oct-Dec. PMID 19147957, Free PMC Article
    3. Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nakamura Y, et al. Nat Commun, 2011. PMID 21427722, Free PMC Article
    4. Itch is required for lateral line development in zebrafish. Angers A, et al. PLoS One, 2014. PMID 25369329, Free PMC Article
    5. Observation of miRNA gene expression in zebrafish embryos by in situ hybridization to microRNA primary transcripts. He X, et al. Zebrafish, 2011 Mar. PMID 21288128, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NEDD4-like E3 ubiquitin-protein ligase WWP2
    NP_001092918.1
    XP_005163228.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099448.1 → NP_001092918.1  NEDD4-like E3 ubiquitin-protein ligase WWP2

      See identical proteins and their annotated locations for NP_001092918.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129043
      UniProtKB/TrEMBL
      A0A2R8RWE6, A2VCZ7, F6PEA4
      Related
      ENSDARP00000154551.1, ENSDART00000185712.1
      Conserved Domains (5) summary
      cd04021
      Location:17 → 145
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      smart00456
      Location:297 → 326
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:535 → 863
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:512 → 864
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:402 → 430
      WW; WW domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      34749179..34804029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163171.5 → XP_005163228.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BAJ0, F6P346
      Related
      ENSDARP00000081798.4, ENSDART00000087364.6
      Conserved Domains (5) summary
      cd04021
      Location:17 → 145
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      smart00456
      Location:298 → 327
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:536 → 864
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:513 → 865
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:403 → 431
      WW; WW domain
    Nucleotide Protein
    Heading Accession and Version

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