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    prkacaa protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [ Danio rerio (zebrafish) ]

    Gene ID: 564064, updated on 18-Sep-2024

    Summary

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    Official Symbol
    prkacaaprovided by ZNC
    Official Full Name
    protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050114-6
    See related
    Ensembl:ENSDARG00000100349 AllianceGenome:ZFIN:ZDB-GENE-050114-6
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:158799
    Summary
    Predicted to enable protein kinase A regulatory subunit binding activity. Predicted to be involved in protein kinase A signaling. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in nucleus. Is expressed in fin bud; hatching gland; nervous system; otic vesicle; and presumptive neural retina. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKACA (protein kinase cAMP-activated catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See prkacaa in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (49458015..49504023, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (45314414..45358612, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene trans-2,3-enoyl-CoA reductase a Neighboring gene sterile alpha motif domain containing 1a Neighboring gene uncharacterized LOC101882145 Neighboring gene anti-silencing function 1Ba histone chaperone Neighboring gene crumbs homolog 3a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. In-vivo detection of binary PKA network interactions upon activation of endogenous GPCRs. Röck R, et al. Sci Rep, 2015 Jun 23. PMID 26099953, Free PMC Article
    2. Developmental expression patterns of protein kinase A catalytic subunits in zebrafish. Emerson SE, et al. Gene Expr Patterns, 2019 Jan. PMID 30468770
    3. DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma. de Oliveira S, et al. Dis Model Mech, 2020 Apr 30. PMID 32102783, Free PMC Article
    4. Mys protein regulates protein kinase A activity by interacting with regulatory type Ialpha subunit during vertebrate development. Kotani T, et al. J Biol Chem, 2010 Feb 12. PMID 20018846, Free PMC Article
    5. Ewing sarcoma ewsa protein regulates chondrogenesis of Meckel's cartilage through modulation of Sox9 in zebrafish. Merkes C, et al. PLoS One, 2015. PMID 25617839, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cAMP-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cAMP-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
    Names
    prkaca
    NP_001076309.1
    XP_021326630.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082840.1 → NP_001076309.1  protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a

      See identical proteins and their annotated locations for NP_001076309.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133159
      UniProtKB/TrEMBL
      A0A8M1NDC7, A3KMS9, E7F7L5
      Related
      ENSDARP00000135348.1, ENSDART00000168108.2
      Conserved Domains (2) summary
      PTZ00263
      Location:42 → 352
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:43 → 332
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      49458015..49504023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470955.2 → XP_021326630.1  protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PZU3
      Conserved Domains (1) summary
      cd14209
      Location:80 → 369
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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