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    Stam2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 [ Mus musculus (house mouse) ]

    Gene ID: 56324, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Stam2provided by MGI
    Official Full Name
    signal transducing adaptor molecule (SH3 domain and ITAM motif) 2provided by MGI
    Primary source
    MGI:MGI:1929100
    See related
    Ensembl:ENSMUSG00000055371 AllianceGenome:MGI:1929100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hbp; 1200004O12Rik; 5730456G07Rik
    Summary
    Predicted to enable phosphatidylinositol binding activity and ubiquitin binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in endocytic vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and skin. Orthologous to human STAM2 (signal transducing adaptor molecule 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 8.5), testis adult (RPKM 7.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stam2 in Genome Data Viewer
    Location:
    2 C1.1; 2 30.41 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (52582213..52632212, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (52692206..52742149, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, beta 4 subunit Neighboring gene STARR-seq mESC enhancer starr_04484 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_04486 Neighboring gene predicted gene, 46740 Neighboring gene STARR-positive B cell enhancer ABC_E7814 Neighboring gene predicted gene, 46741 Neighboring gene STARR-positive B cell enhancer ABC_E10102 Neighboring gene STARR-seq mESC enhancer starr_04490 Neighboring gene formin-like 2 Neighboring gene STARR-seq mESC enhancer starr_04498 Neighboring gene STARR-seq mESC enhancer starr_04499 Neighboring gene predicted gene, 52511 Neighboring gene STARR-positive B cell enhancer ABC_E1005 Neighboring gene pre-mRNA processing factor 40A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons. Kapuralin K, et al. Mol Cell Neurosci, 2015 Jul. PMID 26101075
    2. Stam2 expression pattern during embryo development. Curlin M, et al. Gene Expr Patterns, 2012 Jan-Feb. PMID 22143071
    3. Splice variant of mouse Stam2 mRNA in nervous and muscle tissue contains additional exon with stop codon within region coding for VHS domain. Curlin M, et al. Croat Med J, 2006 Feb. PMID 16489693, Free PMC Article
    4. Expression pattern and functional analysis of mouse Stam2 in the olfactory system. Furić Cunko V, et al. Coll Antropol, 2008 Jan. PMID 18405059
    5. Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival. Yamada M, et al. Mol Cell Biol, 2002 Dec. PMID 12446783, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stam2 is expressed in the nervous tissue, heart, digestive and endocrine system during embryo development.
      Title: Stam2 expression pattern during embryo development.
    2. These results demonstrate that the STAMs are indispensably involved in T-cell development and survival in the thymus through the prevention of apoptosis but are dispensable for the proximal signaling of TCR and cytokine receptors.
      Title: Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival.
    3. SH3 domains of STAM2 and Grb2 retain the moderate characteristics of recognizing their ligand proteins like other SH3 domains for signal protein binding
      Title: Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain.
    4. plays important role in the mammalian endosomal/vacuolar protein sorting pathway
      Title: Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation.
    5. STAM proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway.
      Title: STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    signal transducing adapter molecule 2
    Names
    Hrs binding protein
    STAM-2
    hrs-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418464.1 → NP_001405393.1  signal transducing adapter molecule 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL928960

    2. NM_001418465.1 → NP_001405394.1  signal transducing adapter molecule 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL928960

    3. NM_001418466.1 → NP_001405395.1  signal transducing adapter molecule 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL928960
      Related
      ENSMUSP00000121898.2, ENSMUST00000127316.8

    4. NM_001418467.1 → NP_001405396.1  signal transducing adapter molecule 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL928960

    5. NM_019667.3 → NP_062641.1  signal transducing adapter molecule 2 isoform a

      See identical proteins and their annotated locations for NP_062641.1

      Status: VALIDATED

      Source sequence(s)
      AL928960
      Consensus CDS
      CCDS16037.1
      UniProtKB/Swiss-Prot
      A2AU00, O88811, Q8C8Y4
      UniProtKB/TrEMBL
      Q3TGH8
      Related
      ENSMUSP00000099820.2, ENSMUST00000102759.8
      Conserved Domains (4) summary
      cd11963
      Location:204 → 260
      SH3_STAM2; Src homology 3 domain of Signal Transducing Adaptor Molecule 2
      cd03568
      Location:9 → 143
      VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...
      pfam02809
      Location:166 → 181
      UIM; Ubiquitin interaction motif
      pfam03127
      Location:294 → 367
      GAT; GAT domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      52582213..52632212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88811.1 GenPept UniProtKB/Swiss-Prot:O88811

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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