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    mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 561262, updated on 2-Nov-2024

    Summary

    Official Symbol
    mapk8ip2provided by ZNC
    Official Full Name
    mitogen-activated protein kinase 8 interacting protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070705-326
    See related
    Ensembl:ENSDARG00000063157 AllianceGenome:ZFIN:ZDB-GENE-070705-326
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-180h12.2; si:dkey-181m21.1
    Summary
    Predicted to enable JUN kinase binding activity and MAP-kinase scaffold activity. Predicted to be involved in JNK cascade. Predicted to act upstream of or within phosphorylation and regulation of JNK cascade. Predicted to be active in cytoplasm. Orthologous to human MAPK8IP2 (mitogen-activated protein kinase 8 interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See mapk8ip2 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (8251603..8313167, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (8296416..8355218, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene SH3 and multiple ankyrin repeat domains 3a Neighboring gene golgin subfamily A member 6-like protein 22 Neighboring gene arylsulfatase A Neighboring gene kelch repeat and BTB domain-containing protein 13 Neighboring gene choline kinase beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables JUN kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP-kinase scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    C-Jun-amino-terminal kinase-interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      8251603..8313167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_679994.10XP_685086.6  C-Jun-amino-terminal kinase-interacting protein 2

      UniProtKB/TrEMBL
      A0A8N7T741, F1QF74
      Related
      ENSDARP00000086466.5, ENSDART00000092033.6
      Conserved Domains (2) summary
      cd11942
      Location:10211075
      SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
      cd01212
      Location:10921242
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain