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    micu1 mitochondrial calcium uptake 1 [ Danio rerio (zebrafish) ]

    Gene ID: 561210, updated on 2-Nov-2024

    Summary

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    Official Symbol
    micu1provided by ZNC
    Official Full Name
    mitochondrial calcium uptake 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070410-22
    See related
    Ensembl:ENSDARG00000063358 AllianceGenome:ZFIN:ZDB-GENE-070410-22
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cbara1; zgc:162148
    Summary
    Predicted to enable calcium ion binding activity and calcium ion sensor activity. Predicted to be involved in calcium ion transport; positive regulation of cristae formation; and positive regulation of mitochondrial calcium ion concentration. Predicted to act upstream of or within calcium ion transport. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of uniplex complex. Is expressed in female organism; heart; and heart tube. Human ortholog(s) of this gene implicated in myopathy with extrapyramidal signs. Orthologous to human MICU1 (mitochondrial calcium uptake 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See micu1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (4871997..4969688)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (4743393..4841101)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene oncoprotein induced transcript 3 Neighboring gene mitochondrial calcium uniporter Neighboring gene nucleolar and coiled-body phosphoprotein 1 Neighboring gene mitochondrial ribosomal protein S6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mutation/SNP analysis in EF-hand calcium binding domain of mitochondrial Ca[Formula: see text] uptake 1 gene in bipolar disorder patients. Safari R, et al. J Integr Neurosci, 2016 Jun. PMID 27297032
    2. Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Shimizu H, et al. Elife, 2015 Jan 15. PMID 25588501, Free PMC Article
    3. Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1(-/-) zebrafish. Soman S, et al. Eur J Neurosci, 2017 Feb. PMID 27859782, Free PMC Article
    4. Increasing Ca(2+) in photoreceptor mitochondria alters metabolites, accelerates photoresponse recovery, and reveals adaptations to mitochondrial stress. Hutto RA, et al. Cell Death Differ, 2020 Mar. PMID 31371786, Free PMC Article
    5. A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish. Sabharwal A, et al. Genes (Basel), 2022 Jul 23. PMID 35893052, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC162148

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium ion sensor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium import into the mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion import ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within mitochondrial calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial calcium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cristae formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of mitochondrial calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of uniplex complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of uniplex complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    calcium uptake protein 1, mitochondrial
    Names
    calcium-binding atopy-related autoantigen 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083833.1 → NP_001077302.1  calcium uptake protein 1, mitochondrial

      See identical proteins and their annotated locations for NP_001077302.1

      Status: PROVISIONAL

      Source sequence(s)
      BC134905
      UniProtKB/Swiss-Prot
      A4IG32, B8JIY1, B8JJM2
      Related
      ENSDARP00000121050.1, ENSDART00000132301.3
      Conserved Domains (3) summary
      pfam13202
      Location:234 → 257
      EF-hand_5; EF hand
      pfam13833
      Location:399 → 452
      EF-hand_8; EF-hand domain pair
      pfam15713
      Location:29 → 110
      PTPRCAP; Protein tyrosine phosphatase receptor type C-associated

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      4871997..4969688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068212871.1 → XP_068068972.1  calcium uptake protein 1, mitochondrial isoform X1

    2. XM_005156522.5 → XP_005156579.1  calcium uptake protein 1, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8M2B2V5, E9QGA3
      Related
      ENSDARP00000086953.6, ENSDART00000092521.6
      Conserved Domains (3) summary
      pfam13202
      Location:230 → 253
      EF-hand_5; EF hand
      pfam13833
      Location:395 → 448
      EF-hand_8; EF-hand domain pair
      pfam15713
      Location:29 → 110
      PTPRCAP; Protein tyrosine phosphatase receptor type C-associated
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4IG32.1 GenPept UniProtKB/Swiss-Prot:A4IG32

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