ZC3H15 zinc finger CCCH-type containing 15 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZC3H15provided by HGNC
Official Full Name: zinc finger CCCH-type containing 15provided by HGNC
Primary source: HGNC:HGNC:29528
See related: Ensembl:ENSG00000065548 MIM:619704; AllianceGenome:HGNC:29528
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DFRP1; HT010; LEREPO4; MSTP012
Summary: Enables RNA binding activity and cadherin binding activity. Involved in positive regulation of GTPase activity. Located in cytosol. [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in bone marrow (RPKM 44.3), brain (RPKM 30.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q32.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (186486260..186509361)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (186975546..186998651)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (187350987..187374088)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZC3H15 promotes glioblastoma progression through regulating EGFR stability.
Title: ZC3H15 promotes glioblastoma progression through regulating EGFR stability.
ZC3H15 Correlates with a Poor Prognosis and Tumor Progression in Melanoma.
Title: ZC3H15 Correlates with a Poor Prognosis and Tumor Progression in Melanoma.
ZC3H15 is an independent prognostic marker in hepatocellular carcinoma patients that is clinicopathologically associated with tumor invasion and serum a-fetoprotein levels.
Title: Elevated ZC3H15 increases HCC growth and predicts poor survival after surgical resection.
it is hypothesized that ZC3H15 may interact with TRAF-2 functionally within the NF-kappaB pathway, and may be explored as a potential target in acute myeloid leukemia
Title: Characterization of ZC3H15 as a potential TRAF-2-interacting protein implicated in the NFκB pathway and overexpressed in AML.
Lerepo4 action leaves Drg1 affinity for nucleotides unaffected, feasibly favoring a switch I reorientation, mainly via the TGS domain.
Title: Human Drg1 is a potassium-dependent GTPase enhanced by Lerepo4.
down-regulation of LEREPO4 expression caused a significant inhibition of HIV replication
Title: Inhibition of X4-tropic HIV type 1 replication by knockdown of the cellular protein LEREPO4.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH121216 (e-PCR)
- UniSTS:138327

RH70209 (e-PCR)
- UniSTS:14214

A009S24 (e-PCR)
- UniSTS:48522

G32811 (e-PCR)
- UniSTS:117390

T16069 (e-PCR)
- UniSTS:60413

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger CCCH domain-containing protein 15

Names: DRG family-regulatory protein 1; likely ortholog of mouse immediate early response erythropoietin 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018471.3 → NP_060941.2 zinc finger CCCH domain-containing protein 15

See identical proteins and their annotated locations for NP_060941.2

Status: VALIDATED

Source sequence(s)

AL040058, BC021102

Consensus CDS

CCDS42791.1

UniProtKB/Swiss-Prot

B4DMW2, D3DPG7, Q5QTQ4, Q8WU90, Q8WZ06, Q9NUZ3, Q9NZ37, Q9P079

UniProtKB/TrEMBL

B7Z592

Related

ENSP00000338788.6, ENST00000337859.11

Conserved Domains (3) summary

smart00356
Location:99 → 125

ZnF_C3H1; zinc finger

COG5252
Location:1 → 325

COG5252; Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only]

pfam16543
Location:230 → 312

DFRP_C; DRG Family Regulatory Proteins, Tma46