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    adcy2b adenylate cyclase 2b (brain) [ Danio rerio (zebrafish) ]

    Gene ID: 557902, updated on 17-Sep-2024

    Summary

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    Official Symbol
    adcy2bprovided by ZNC
    Official Full Name
    adenylate cyclase 2b (brain)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-69
    See related
    Ensembl:ENSDARG00000014588 AllianceGenome:ZFIN:ZDB-GENE-060503-69
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-266i6.1
    Summary
    Predicted to enable adenylate cyclase activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within cAMP biosynthetic process and intracellular signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human ADCY2 (adenylate cyclase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See adcy2b in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (27609618..27776689, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (28025395..28192692, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-46h3.2 Neighboring gene cilia and flagella associated protein 90 Neighboring gene terminal nucleotidyltransferase 4A Neighboring gene steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A comparative expression analysis of gene transcripts in brain tissue of non-transgenic and GH-transgenic zebrafish (Danio rerio) using a DDRT-PCR approach. Alves-Costa FA, et al. An Acad Bras Cienc, 2012 Jun. PMID 22584411
    2. The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa. Nakao T, et al. PLoS One, 2012. PMID 22485131, Free PMC Article
    3. Testicular transcriptome alterations in zebrafish (Danio rerio) exposure to 17β-estradiol. Zheng Y, et al. Chemosphere, 2019 Mar. PMID 30465971
    4. Organization of Iroquois genes in fish. Dildrop R, et al. Dev Genes Evol, 2004 Jun. PMID 15133664
    5. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cAMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenylate cyclase type 2b
    NP_001093457.1
    XP_005170095.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099987.1 → NP_001093457.1  adenylate cyclase type 2b

      Status: PROVISIONAL

      Source sequence(s)
      BX511155, CR759914
      UniProtKB/TrEMBL
      A0A8M1NDL5, Q1L8K1
      Related
      ENSDARP00000119823.1, ENSDART00000135348.3
      Conserved Domains (4) summary
      smart00044
      Location:283 → 486
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:926 → 1125
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:542 → 643
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:80 → 307
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      27609618..27776689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170038.5 → XP_005170095.1  adenylate cyclase type 2b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHB8, F1Q5J6
      Related
      ENSDARP00000046165.6, ENSDART00000046166.9
      Conserved Domains (4) summary
      smart00044
      Location:283 → 486
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:929 → 1128
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:542 → 646
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:80 → 307
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    RNA

    1. XR_002456106.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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