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    panx2 pannexin 2 [ Danio rerio (zebrafish) ]

    Gene ID: 557828, updated on 2-Nov-2024

    Summary

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    Official Symbol
    panx2provided by ZNC
    Official Full Name
    pannexin 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050419-55
    See related
    Ensembl:ENSDARG00000063019 AllianceGenome:ZFIN:ZDB-GENE-050419-55
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-192n14.2
    Summary
    Predicted to enable wide pore channel activity. Predicted to be involved in cell-cell signaling and monoatomic cation transport. Predicted to act upstream of or within monoatomic ion transmembrane transport and positive regulation of interleukin-1 production. Located in cytoplasmic vesicle. Is expressed in brain; eye; and heart. Orthologous to human PANX2 (pannexin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See panx2 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (14903274..14922872, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (14938058..14954360, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene selenoprotein O1 Neighboring gene TraB domain containing Neighboring gene modulator of VRAC current 1 Neighboring gene BTB (POZ) domain containing 11b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Pannexin1 channel proteins in the zebrafish retina have shared and unique properties. Kurtenbach S, et al. PLoS One, 2013. PMID 24194896, Free PMC Article
    2. Pannexin 1 ohnologs in the teleost lineage. Bond SR, et al. J Membr Biol, 2012 Aug. PMID 22922822
    3. Molecular diversity of connexin and pannexin genes in the retina of the zebrafish Danio rerio. Zoidl G, et al. Cell Commun Adhes, 2008 May. PMID 18649188
    4. Panx1b Modulates the Luminance Response and Direction of Locomotion in the Zebrafish. Safarian N, et al. Int J Mol Sci, 2021 Oct 29. PMID 34769181, Free PMC Article
    5. Cx23, a connexin with only four extracellular-loop cysteines, forms functional gap junction channels and hemichannels. Iovine MK, et al. FEBS Lett, 2008 Jan 23. PMID 18068130, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables wide pore channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of interleukin-1 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pannexin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256641.1 → NP_001243570.1  pannexin-2

      See identical proteins and their annotated locations for NP_001243570.1

      Status: PROVISIONAL

      Source sequence(s)
      EU252024
      UniProtKB/TrEMBL
      B1P2E8
      Related
      ENSDARP00000086155.6, ENSDART00000091722.6
      Conserved Domains (1) summary
      cl03000
      Location:52 → 161
      Innexin; Innexin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      14903274..14922872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017351929.3 → XP_017207418.1  pannexin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YTH1, F1QKJ1
      Conserved Domains (1) summary
      cl03000
      Location:59 → 161
      Innexin; Innexin

    2. XM_021467660.2 → XP_021323335.1  pannexin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YTH1, F1QKJ1
      Conserved Domains (1) summary
      cl03000
      Location:59 → 161
      Innexin; Innexin
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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