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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001104526.1 → NP_001097996.1 triple functional domain protein
Status: PROVISIONAL
- Source sequence(s)
-
BX950864, BX957244
- UniProtKB/Swiss-Prot
-
Q1LUA6
- UniProtKB/TrEMBL
- A0A8M1NFT5, F1Q551
- Related
- ENSDARP00000081489.4, ENSDART00000087055.6
- Conserved Domains (13) summary
-
- cd11852
Location:1668 → 1727
- SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
- cd11853
Location:2543 → 2601
- SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
- smart00220
Location:2785 → 3039
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- smart00516
Location:69 → 207
- SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
- cd00160
Location:1303 → 1475
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd00176
Location:577 → 793
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam07679
Location:2674 → 2765
- I-set; Immunoglobulin I-set domain
- cd13240
Location:1482 → 1604
- PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
- cd13241
Location:2158 → 2297
- PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
- pfam00621
Location:1983 → 2154
- RhoGEF; RhoGEF domain
- pfam16609
Location:1724 → 1982
- SH3-RhoG_link; SH3-RhoGEF linking unstructured region
- cl11960
Location:2691 → 2765
- Ig; Immunoglobulin domain
- cl21453
Location:2777 → 3039
- PKc_like; Protein Kinases, catalytic domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCz11 Primary Assembly
Genomic
-
NC_007130.7 Reference GRCz11 Primary Assembly
- Range
-
41838100..41991283 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_021468076.2 → XP_021323751.1 triple functional domain protein isoform X2
- UniProtKB/Swiss-Prot
-
Q1LUA6
- UniProtKB/TrEMBL
-
A0A8M9PNC1
- Conserved Domains (12) summary
-
- smart00150
Location:1166 → 1266
- SPEC; Spectrin repeats
- cd11852
Location:1695 → 1754
- SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
- cd11853
Location:2570 → 2628
- SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
- smart00516
Location:61 → 199
- SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
- cd00160
Location:2007 → 2180
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd00176
Location:590 → 806
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam07679
Location:2701 → 2792
- I-set; Immunoglobulin I-set domain
- cd13240
Location:1495 → 1627
- PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
- cd13241
Location:2185 → 2324
- PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
- pfam16609
Location:1752 → 2000
- SH3-RhoG_link; SH3-RhoGEF linking unstructured region
- cl21453
Location:2804 → 3066
- PKc_like; Protein Kinases, catalytic domain
- cl26464
Location:2364 → 2523
- Atrophin-1; Atrophin-1 family
-
XM_021468077.2 → XP_021323752.1 triple functional domain protein isoform X3
- UniProtKB/Swiss-Prot
-
Q1LUA6
- UniProtKB/TrEMBL
-
A0A8M9P1U8
- Conserved Domains (12) summary
-
- smart00150
Location:1166 → 1266
- SPEC; Spectrin repeats
- cd11852
Location:1695 → 1754
- SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
- cd11853
Location:2570 → 2628
- SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
- smart00516
Location:61 → 199
- SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
- cd00160
Location:2007 → 2180
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd00176
Location:590 → 806
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam07679
Location:2698 → 2789
- I-set; Immunoglobulin I-set domain
- cd13240
Location:1495 → 1627
- PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
- cd13241
Location:2185 → 2324
- PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
- pfam16609
Location:1752 → 2000
- SH3-RhoG_link; SH3-RhoGEF linking unstructured region
- cl21453
Location:2801 → 3063
- PKc_like; Protein Kinases, catalytic domain
- cl26464
Location:2364 → 2523
- Atrophin-1; Atrophin-1 family
-
XM_009294421.4 → XP_009292696.1 triple functional domain protein isoform X6
- UniProtKB/Swiss-Prot
-
Q1LUA6
- UniProtKB/TrEMBL
-
A0A8M3ASV0
- Conserved Domains (13) summary
-
- cd11852
Location:1664 → 1723
- SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
- cd11853
Location:2539 → 2597
- SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
- smart00220
Location:2781 → 3035
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- smart00516
Location:61 → 199
- SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
- cd00160
Location:1295 → 1467
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd00176
Location:569 → 785
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam07679
Location:2670 → 2761
- I-set; Immunoglobulin I-set domain
- cd13240
Location:1474 → 1596
- PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
- cd13241
Location:2154 → 2293
- PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
- pfam00621
Location:1979 → 2150
- RhoGEF; RhoGEF domain
- pfam16609
Location:1720 → 1978
- SH3-RhoG_link; SH3-RhoGEF linking unstructured region
- cl11960
Location:2687 → 2761
- Ig; Immunoglobulin domain
- cl21453
Location:2773 → 3035
- PKc_like; Protein Kinases, catalytic domain
-
XM_021468075.2 → XP_021323750.1 triple functional domain protein isoform X1
- UniProtKB/Swiss-Prot
-
Q1LUA6
- UniProtKB/TrEMBL
-
A0A8M9PRK6
- Conserved Domains (12) summary
-
- smart00150
Location:1166 → 1266
- SPEC; Spectrin repeats
- cd11852
Location:1695 → 1754
- SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
- cd11853
Location:2570 → 2628
- SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
- smart00516
Location:61 → 199
- SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
- cd00160
Location:2007 → 2180
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd00176
Location:590 → 806
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam07679
Location:2702 → 2793
- I-set; Immunoglobulin I-set domain
- cd13240
Location:1495 → 1627
- PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
- cd13241
Location:2185 → 2324
- PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
- pfam16609
Location:1752 → 2000
- SH3-RhoG_link; SH3-RhoGEF linking unstructured region
- cl21453
Location:2805 → 3067
- PKc_like; Protein Kinases, catalytic domain
- cl26464
Location:2364 → 2523
- Atrophin-1; Atrophin-1 family
-
XM_021468079.2 → XP_021323754.1 triple functional domain protein isoform X5
- UniProtKB/TrEMBL
-
A0A8M9PGG0
- Conserved Domains (8) summary
-
- smart00150
Location:1166 → 1266
- SPEC; Spectrin repeats
- cd11852
Location:1695 → 1754
- SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
- smart00516
Location:61 → 199
- SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
- cd00160
Location:2007 → 2180
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd00176
Location:590 → 806
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- cd13240
Location:1495 → 1627
- PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
- cd13241
Location:2185 → 2316
- PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
- pfam16609
Location:1752 → 2000
- SH3-RhoG_link; SH3-RhoGEF linking unstructured region
-
XM_021468078.2 → XP_021323753.1 triple functional domain protein isoform X4
- UniProtKB/TrEMBL
-
A0A8M9PAZ8
- Conserved Domains (8) summary
-
- smart00150
Location:1166 → 1266
- SPEC; Spectrin repeats
- cd11852
Location:1695 → 1754
- SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
- smart00516
Location:61 → 199
- SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
- cd00160
Location:2007 → 2180
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd00176
Location:590 → 806
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- cd13240
Location:1495 → 1627
- PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
- cd13241
Location:2185 → 2324
- PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
- pfam16609
Location:1752 → 2000
- SH3-RhoG_link; SH3-RhoGEF linking unstructured region