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    prkcq protein kinase C, theta [ Danio rerio (zebrafish) ]

    Gene ID: 555521, updated on 2-Nov-2024

    Summary

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    Official Symbol
    prkcqprovided by ZNC
    Official Full Name
    protein kinase C, thetaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041210-195
    See related
    Ensembl:ENSDARG00000034173 AllianceGenome:ZFIN:ZDB-GENE-041210-195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-239o15.1
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Located in immunological synapse. Is expressed in Mauthner neurons; brain; somite border; and spinal cord. Orthologous to human PRKCQ (protein kinase C theta). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See prkcq in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (25391191..25443129)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (25402023..25453607)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 110, like Neighboring gene Scm like with four mbt domains 2 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Neighboring gene RNA binding motif protein 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterisation of amphioxus protein kinase C-δ/θ reveals a unique proto-V3 domain suggesting an evolutionary mechanism for PKC-θ unique V3. Chen ZL, et al. Fish Shellfish Immunol, 2019 Jan. PMID 30408601
    2. Differential expression of PKC isoforms in developing zebrafish. Patten SA, et al. Int J Dev Neurosci, 2007 May. PMID 17403595
    3. Expression and localization of grass carp pkc-θ (protein kinase C theta) gene after its activation. Mehjabin R, et al. Fish Shellfish Immunol, 2019 Apr. PMID 30716520
    4. Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-Cell RNA-Seq. Pandey S, et al. Curr Biol, 2018 Apr 2. PMID 29576475, Free PMC Article
    5. Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection. Lin C, et al. BMC Syst Biol, 2014. PMID 25603810, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein kinase C theta type
    NP_001082839.2
    XP_009298659.1
    XP_009298660.1
    XP_068075734.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089370.2 → NP_001082839.2  protein kinase C theta type

      See identical proteins and their annotated locations for NP_001082839.2

      Status: VALIDATED

      Source sequence(s)
      AL954652
      UniProtKB/TrEMBL
      A0A8M1NE42, F1R506
      Related
      ENSDARP00000046252.5, ENSDART00000046253.5
      Conserved Domains (3) summary
      smart00220
      Location:386 → 640
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05619
      Location:380 → 710
      STKc_nPKC_theta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta
      pfam00130
      Location:232 → 284
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      25391191..25443129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068219633.1 → XP_068075734.1  protein kinase C theta type isoform X1

    2. XM_009300385.4 → XP_009298660.1  protein kinase C theta type isoform X1

      See identical proteins and their annotated locations for XP_009298660.1

      UniProtKB/TrEMBL
      A0A8M3B909
      Conserved Domains (3) summary
      smart00220
      Location:392 → 646
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05619
      Location:386 → 716
      STKc_nPKC_theta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta
      pfam00130
      Location:238 → 290
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    3. XM_009300384.4 → XP_009298659.1  protein kinase C theta type isoform X1

      See identical proteins and their annotated locations for XP_009298659.1

      UniProtKB/TrEMBL
      A0A8M3B909
      Related
      ENSDARP00000108813.2, ENSDART00000123680.3
      Conserved Domains (3) summary
      smart00220
      Location:392 → 646
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05619
      Location:386 → 716
      STKc_nPKC_theta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta
      pfam00130
      Location:238 → 290
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein Strain
    Heading Accession and Version

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