U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    MCL1 MCL1 apoptosis regulator, BCL2 family member [ Ovis aries (sheep) ]

    Gene ID: 554329, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    MCL1
    Gene description
    MCL1 apoptosis regulator, BCL2 family member
    See related
    EnsemblRapid:ENSOARG00020008725
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Also known as
    Mcl-1
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MCL1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 1 NC_056054.1 (100590177..100594862, complement)

    Chromosome 1 - NC_056054.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105612466 Neighboring gene ADAMTS like 4 Neighboring gene transfer RNA glutamic acid (anticodon CUC) Neighboring gene endosulfine alpha Neighboring gene ubiquitin-ribosomal protein eS31 fusion protein-like Neighboring gene golgi phosphoprotein 3 like Neighboring gene HORMA domain containing 1 Neighboring gene enhancer of rudimentary homolog

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_056054.1 Chromosome 1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Positional and functional characterisation of apoptosis related genes belonging to the BCL2 family in sheep. Lyahyai J, et al. Cytogenet Genome Res, 2005. PMID 15905648

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitochondrial fusion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    induced myeloid leukemia cell differentiation protein Mcl-1
    Names
    BCL2 family apoptosis regulator
    Bcl-2-related protein
    MCL1, BCL2 family apoptosis regulator
    myeloid cell leukemia protein 1
    myeloid cell leukemia sequence 1 (BCL2-related)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056054.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      100590177..100594862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015092234.3 → XP_014947720.2  induced myeloid leukemia cell differentiation protein Mcl-1

      UniProtKB/TrEMBL
      A0A6P3YF80
      Related
      ENSOARP00020011012.1, ENSOART00020013369.2
      Conserved Domains (1) summary
      cd06845
      Location:175 → 318
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials