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    NKX2-2 NK2 homeobox 2 [ Ovis aries (sheep) ]

    Gene ID: 554253, updated on 5-Mar-2024

    Summary

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    Gene symbol
    NKX2-2
    Gene description
    NK2 homeobox 2
    See related
    EnsemblRapid:ENSOARG00020004554
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Also known as
    NKX2.2
    Orthologs
    human mouse all
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    Genomic context

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    See NKX2-2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 13 NC_056066.1 (40322428..40333722, complement)

    Chromosome 13 - NC_056066.1Genomic Context describing neighboring genes Neighboring gene 5'-3' exoribonuclease 2 Neighboring gene dual specificity protein phosphatase 12-like Neighboring gene NK2 homeobox 4 Neighboring gene uncharacterized LOC121816265 Neighboring gene paired box 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056066.1 Chromosome 13 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox protein Nkx-2.2
    Names
    NK2 transcription factor related locus 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056066.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      40322428..40333722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015099673.4 → XP_014955159.2  homeobox protein Nkx-2.2

      UniProtKB/TrEMBL
      A0A6P3YKS4, Q4TVN1
      Related
      ENSOARP00020038852.1, ENSOART00020065890.1
      Conserved Domains (1) summary
      pfam00046
      Location:131 → 185
      Homeobox; Homeobox domain

    2. XM_042229641.2 → XP_042085575.1  homeobox protein Nkx-2.2

      UniProtKB/TrEMBL
      A0A6P3YKS4, Q4TVN1
      Conserved Domains (1) summary
      pfam00046
      Location:131 → 185
      Homeobox; Homeobox domain
    Nucleotide Protein Strain
    Heading Accession and Version

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