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    rhobtb4 Rho related BTB domain containing 4 [ Danio rerio (zebrafish) ]

    Gene ID: 553415, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rhobtb4provided by ZNC
    Official Full Name
    Rho related BTB domain containing 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060315-11
    See related
    Ensembl:ENSDARG00000016868 AllianceGenome:ZFIN:ZDB-GENE-060315-11
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rhobtb2a
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; engulfment of apoptotic cell; and regulation of cell shape. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See rhobtb4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (43427891..43509101)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (42827732..42903939)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene U5 spliceosomal RNA Neighboring gene transfer RNA aspartic acid (anticodon GUC) Neighboring gene si:dkey-40c11.2 Neighboring gene rhotekin a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. Fazio M, et al. Elife, 2021 Feb 2. PMID 33527896, Free PMC Article
    2. Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Salas-Vidal E, et al. Genomics, 2005 Jul. PMID 15894457
    3. Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components. van der Sar AM, et al. Mol Immunol, 2009 Jul. PMID 19409617
    4. Understanding the complexity of epimorphic regeneration in zebrafish caudal fin tissue: A transcriptomic and proteomic approach. Banu S, et al. Genomics, 2022 Mar. PMID 35134499
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rho related BTB domain containing 4
    Names
    Rho-related BTB domain containing 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099974.2 → NP_001093444.1  Rho related BTB domain containing 4 isoform 2

      See identical proteins and their annotated locations for NP_001093444.1

      Status: VALIDATED

      Source sequence(s)
      BX784028, CR812476
      UniProtKB/TrEMBL
      A0A8M2BCP0, A2BI17
      Related
      ENSDARP00000144243.1, ENSDART00000177895.2
      Conserved Domains (5) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      smart00174
      Location:17 → 208
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      smart00225
      Location:502 → 599
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:492 → 594
      BTB; BTB/POZ domain
      cl02518
      Location:427 → 469
      BTB; BTB/POZ domain

    2. NM_001365558.1 → NP_001352487.1  Rho related BTB domain containing 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX784028, CR812476
      UniProtKB/TrEMBL
      A0A8M2BCL5, F1RD19
      Related
      ENSDARP00000051113.6, ENSDART00000051114.8
      Conserved Domains (3) summary
      cd01873
      Location:26 → 220
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      pfam00651
      Location:505 → 612
      BTB; BTB/POZ domain
      cl28614
      Location:426 → 486
      BTB; Broad-Complex, Tramtrack and Bric a brac

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      43427891..43509101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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