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    abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 [ Danio rerio (zebrafish) ]

    Gene ID: 553281, updated on 2-Nov-2024

    Summary

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    Official Symbol
    abcc8provided by ZNC
    Official Full Name
    ATP-binding cassette, sub-family C (CFTR/MRP), member 8provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050517-22
    See related
    Ensembl:ENSDARG00000051879 AllianceGenome:ZFIN:ZDB-GENE-050517-22
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sur1
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Acts upstream of or within cellular response to glucose stimulus. Predicted to be located in plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in membrane. Is expressed in diencephalon; forebrain; hindbrain; and midbrain. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple) and hypertension. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See abcc8 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (22720149..22849283)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (22622598..22751730)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily containing leucine-rich repeat 2 Neighboring gene Usher syndrome 1C Neighboring gene potassium inwardly rectifying channel subfamily J member 11 Neighboring gene MOB kinase activator 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genome-edited zebrafish model of ABCC8 loss-of-function disease. Ikle JM, et al. Islets, 2022 Dec 31. PMID 36458573, Free PMC Article
    2. ATP-sensitive potassium channels in zebrafish cardiac and vascular smooth muscle. Singareddy SS, et al. J Physiol, 2022 Jan. PMID 34820842, Free PMC Article
    3. Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells. Emfinger CH, et al. R Soc Open Sci, 2017 Feb. PMID 28386438, Free PMC Article
    4. Identification and characterization of a novel member of the ATP-sensitive K+ channel subunit family, Kir6.3, in zebrafish. Zhang C, et al. Physiol Genomics, 2006 Feb 14. PMID 16317080
    5. Control of metazoan heme homeostasis by a conserved multidrug resistance protein. Korolnek T, et al. Cell Metab, 2014 Jun 3. PMID 24836561, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfonylurea receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family C member 8
    Names
    sulfonylurea receptor subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172647.2 → NP_001166118.2  ATP-binding cassette sub-family C member 8

      Status: VALIDATED

      Source sequence(s)
      BC163553, EB910253, EE213334
      UniProtKB/TrEMBL
      A0A8M1NTE0
      Related
      ENSDARP00000124481.1, ENSDART00000149455.3
      Conserved Domains (4) summary
      TIGR00957
      Location:26 → 1578
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      pfam00664
      Location:1025 → 1294
      ABC_membrane; ABC transporter transmembrane region
      cl00549
      Location:375 → 590
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:1342 → 1581
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      22720149..22849283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170687.5 → XP_005170744.1  ATP-binding cassette sub-family C member 8 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BI16, F1QMZ9
      Related
      ENSDARP00000082855.4, ENSDART00000088422.6
      Conserved Domains (4) summary
      TIGR00957
      Location:39 → 1591
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      pfam00664
      Location:1038 → 1307
      ABC_membrane; ABC transporter transmembrane region
      cl00549
      Location:388 → 603
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:1355 → 1594
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395204.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      23889..144547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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