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    ING3 inhibitor of growth family member 3 [ Homo sapiens (human) ]

    Gene ID: 54556, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ING3provided by HGNC
    Official Full Name
    inhibitor of growth family member 3provided by HGNC
    Primary source
    HGNC:HGNC:14587
    See related
    Ensembl:ENSG00000071243 MIM:607493; AllianceGenome:HGNC:14587
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Eaf4; ING2; MEAF4; p47ING3
    Summary
    The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 18.3), lymph node (RPKM 6.0) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ING3 in Genome Data Viewer
    Location:
    7q31.31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (120950777..120977216)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (122266123..122292563)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (120590831..120617270)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily D member 2 Neighboring gene RNA, U6 small nuclear 581, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr7:120422555-120423072 Neighboring gene Sharpr-MPRA regulatory region 15278 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18572 Neighboring gene tetraspanin 12 Neighboring gene uncharacterized LOC124901733 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:120497141-120497360 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18573 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:120508165-120508289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26555 Neighboring gene uncharacterized LOC124901734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26556 Neighboring gene RNA, 5S ribosomal pseudogene 240 Neighboring gene Sharpr-MPRA regulatory region 12289 Neighboring gene cadherin like and PC-esterase domain containing 1 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Downregulated inhibitor of growth 3 (ING3) expression during colorectal carcinogenesis. Gou WF, et al. Indian J Med Res, 2014 Apr. PMID 24927342, Free PMC Article
    2. ING3 is associated with increased cell invasion and lethal outcome in ERG-negative prostate cancer patients. Almami A, et al. Tumour Biol, 2016 Jul. PMID 26803516
    3. Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. Gunduz M, et al. Oncogene, 2002 Jun 27. PMID 12080476
    4. A Novel Splice Variant of the Inhibitor of Growth 3 Lacks the Plant Homeodomain and Regulates Epithelial-Mesenchymal Transition in Prostate Cancer Cells. Melekhova A, et al. Biomolecules, 2021 Aug 4. PMID 34439818, Free PMC Article
    5. Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation. Song Y, et al. Nucleic Acids Res, 2021 Dec 16. PMID 34791430, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling.
      Title: ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling.
    2. ING Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate Cancer.
      Title: ING Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate Cancer.
    3. Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation.
      Title: Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation.
    4. ING3 and ING4 immunoexpression and their relation to the development of benign odontogenic lesions.
      Title: ING3 and ING4 immunoexpression and their relation to the development of benign odontogenic lesions.
    5. A Novel Splice Variant of the Inhibitor of Growth 3 Lacks the Plant Homeodomain and Regulates Epithelial-Mesenchymal Transition in Prostate Cancer Cells.
      Title: A Novel Splice Variant of the Inhibitor of Growth 3 Lacks the Plant Homeodomain and Regulates Epithelial-Mesenchymal Transition in Prostate Cancer Cells.
    6. Downregulation of nuclear ING3 expression and translocalization to cytoplasm promotes tumorigenesis and progression in head and neck squamous cell carcinoma (HNSCC).
      Title: Downregulation of nuclear ING3 expression and translocalization to cytoplasm promotes tumorigenesis and progression in head and neck squamous cell carcinoma (HNSCC).
    7. Nuclear localization of ING3 is required to suppress melanoma cell migration, invasion and angiogenesis.
      Title: Nuclear localization of ING3 is required to suppress melanoma cell migration, invasion and angiogenesis.
    8. ING3 is required for ATM signaling and DNA repair in response to DNA double strand breaks.
      Title: ING3 is required for ATM signaling and DNA repair in response to DNA double strand breaks.
    9. Data show that ING3 associates with gene promoters to regulate a transcriptional network that is required for cellular proliferation. Importantly, ING3 elevated copy number and protein levels in cancer patients, particularly in treatment-resistant patients, designate ING3 as a novel marker of poor survival for cancer patients and an unsuspected oncoprotein.
      Title: Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein.
    10. results reveal the molecular mechanism of H3K4me3 selection by the ING3PHD and suggest that this interaction is important for mediating ING3 tumor suppressive activities.
      Title: Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20089

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to histone H2A acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone H4 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4K12 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4K16 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4K5 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4K8 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of double-strand break repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Swr1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of piccolo histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inhibitor of growth protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023322.1 RefSeqGene

      Range
      5015..31454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_019071.3 → NP_061944.2  inhibitor of growth protein 3 isoform 1

      See identical proteins and their annotated locations for NP_061944.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC004537, AF074968, AK000096, BU677936, BU684039
      Consensus CDS
      CCDS5778.1
      UniProtKB/Swiss-Prot
      A8K790, O60394, Q567P3, Q6GMT3, Q7Z762, Q969G0, Q96DT4, Q9HC99, Q9NXR8, Q9P081
      UniProtKB/TrEMBL
      Q5GRH6
      Related
      ENSP00000320566.5, ENST00000315870.10
      Conserved Domains (3) summary
      COG5034
      Location:4 → 410
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15585
      Location:362 → 406
      PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
      pfam12998
      Location:3 → 102
      ING; Inhibitor of growth proteins N-terminal histone-binding

    2. NM_198267.2 → NP_938008.1  inhibitor of growth protein 3 isoform 3

      See identical proteins and their annotated locations for NP_938008.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses a different segment in its 3' coding region and UTR, compared to variant 1, with a resulting frameshift. The predicted isoform (3) has a distinct and shorter C-terminus, as compared to isoform 1. This transcript is supported by several ESTs, but the predicted ORF has not yet been experimentally confirmed.
      Source sequence(s)
      AK000096, BC009777, CA442734
      Consensus CDS
      CCDS35497.1
      UniProtKB/TrEMBL
      A0A0C4DG38
      Related
      ENSP00000341697.5, ENST00000339121.9
      Conserved Domains (1) summary
      pfam12998
      Location:3 → 89
      ING; Inhibitor of growth proteins N-terminal histone-binding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      120950777..120977216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420535.1 → XP_047276491.1  inhibitor of growth protein 3 isoform X1

      Related
      ENSP00000410406.1, ENST00000427726.5

    2. XM_017012369.3 → XP_016867858.1  inhibitor of growth protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG38, B7ZKQ7
      Related
      ENSP00000395719.1, ENST00000445699.5
      Conserved Domains (1) summary
      pfam12998
      Location:3 → 89
      ING; Inhibitor of growth proteins N-terminal histone-binding

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      122266123..122292563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358511.1 → XP_054214486.1  inhibitor of growth protein 3 isoform X1

    2. XM_054358512.1 → XP_054214487.1  inhibitor of growth protein 3 isoform X2

      UniProtKB/TrEMBL
      B7ZKQ7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198266.1: Suppressed sequence

      Description
      NM_198266.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NXR8.2 GenPept UniProtKB/Swiss-Prot:Q9NXR8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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