Cacna1e calcium voltage-gated channel subunit alpha1 E [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cacna1eprovided by RGD
Official Full Name: calcium voltage-gated channel subunit alpha1 Eprovided by RGD
Primary source: RGD:2246
See related: EnsemblRapid:ENSRNOG00000002863 AllianceGenome:RGD:2246
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cav2.3; CACHA1E
Summary: Enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in calcium ion import and regulation of synaptic vesicle exocytosis. Located in perikaryon. Part of voltage-gated calcium channel complex. Is active in GABA-ergic synapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 69. Orthologous to human CACNA1E (calcium voltage-gated channel subunit alpha1 E). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 224.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21

Exon count:: 53

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (69125048..69613795, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (66574659..67063443, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (71899445..72534992, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cav1.2 and Cav2.3 in colonic primary sensory neurons play an important role in visceral inflammatory hyperalgesia, which maybe the potential therapeutic targets.
Title: Role of voltage gated Ca2+ channels in rat visceral hypersensitivity change induced by 2,4,6-trinitrobenzene sulfonic acid.
(Cav2.3) Inhibition of R-type calcium channel, Cav2.3, significantly improves cerebral blood flow following subarachnoid hemorrhage.
Title: Antagonism of R-type calcium channels significantly improves cerebral blood flow after subarachnoid hemorrhage in rats.
quartet of leucine residues in the guanylate kinase domain of CaVbeta determines the plasma membrane density of the CaV2.3 channel.
Title: A quartet of leucine residues in the guanylate kinase domain of CaVβ determines the plasma membrane density of the CaV2.3 channel.
identified in the Cav2.3 domain I two sets of amino acids that are responsible of the sensitivity of activation potential (Va) and maximal whole cell conductance (G) to pHo variations
Title: Two sets of amino acids of the domain I of Cav2.3 Ca(2+) channels contribute to their high sensitivity to extracellular protons.
Calcium channel voltage-dependent L type alpha 1E subunit (CACNA1E) polymorphisms are associated with individual variability in seizure susceptibility of Sprague-Dawley rats.
Title: Polymorphisms in CACNA1E and Camk2d are associated with seizure susceptibility of Sprague-Dawley rats.
Essential in Ca++ selectivity over other divalent cations, at a conserved EEEE locus
Title: Molecular determinant for specific Ca/Ba selectivity profiles of low and high threshold Ca2+ channels.
alpha1E-containing voltage-dependent calcium channels (VDCCs) shift the threshold for mossy fiber LTP
Title: Alpha1E-containing Ca2+ channels are involved in synaptic plasticity.
mRNA transcripts for the voltage-gated Ca2+ channel alpha 1E subunit have been detected in rat astrocytes.
Title: Expression of voltage-gated Ca2+ channel subtypes in cultured astrocytes.
Identification of the calcium channel alpha 1E (Ca(v)2.3) isoform expressed in atrial myocytes
Title: Identification of the calcium channel alpha 1E (Ca(v)2.3) isoform expressed in atrial myocytes.
Neurons in the inferior colliculus express Ca(2+) channel alpha(1A), alpha(1B), alpha(1C), alpha(1D), and alpha(1E) subunits.
Title: Voltage-gated calcium channels in adult rat inferior colliculus neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

AW530514 (e-PCR)
- UniSTS:244529

BE119343 (e-PCR)
- UniSTS:249167

Ptp4a1 (e-PCR), detects polymorphism
- UniSTS:527509

BF409484 (e-PCR)
- UniSTS:248984

Cacna1e (e-PCR), detects polymorphism
- UniSTS:141211

D13Got45 (e-PCR)
- UniSTS:115370

RH142860 (e-PCR)
- UniSTS:232107

RH71332 (e-PCR)
- UniSTS:25568

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables high voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables low voltage-gated calcium channel activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	EXP Inferred from Experiment more info	PubMed
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral fear response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavioral response to pain	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fear response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of heart rate	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of somatostatin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle exocytosis	EXP Inferred from Experiment more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in somatodendritic compartment	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: voltage-dependent R-type calcium channel subunit alpha-1E

Names: BII; RBE-II; RBE2; brain calcium channel II; calcium channel, L type, alpha-1 polypeptide; calcium channel, voltage-dependent, L type, alpha 1E subunit; calcium channel, voltage-dependent, R type, alpha 1E subunit; voltage gated calcium channel alpha1E subunit; voltage-dependent calcium channel alpha1-E subunit; voltage-gated calcium channel subunit alpha Cav2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019294.3 → NP_062167.3 voltage-dependent R-type calcium channel subunit alpha-1E

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

Q923K6

Related

ENSRNOP00000003869.9, ENSRNOT00000003869.10

Conserved Domains (4) summary

pfam00520
Location:1460 → 1717

Ion_trans; Ion transport protein

pfam03154
Location:2001 → 2260

Atrophin-1; Atrophin-1 family

pfam08763
Location:1790 → 1863

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1726 → 1779

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

69125048..69613795 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091008.2 → XP_038946936.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

UniProtKB/TrEMBL

Q923K6

Conserved Domains (4) summary

pfam00520
Location:1625 → 1882

Ion_trans; Ion transport protein

pfam03154
Location:2170 → 2429

Atrophin-1; Atrophin-1 family

pfam08763
Location:1955 → 2028

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1891 → 1944

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_039091012.2 → XP_038946940.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X5

UniProtKB/TrEMBL

F1LMS1

Conserved Domains (4) summary

pfam00520
Location:1621 → 1878

Ion_trans; Ion transport protein

pfam03154
Location:2166 → 2425

Atrophin-1; Atrophin-1 family

pfam08763
Location:1951 → 2024

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1887 → 1940

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_039091010.2 → XP_038946938.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X2

UniProtKB/TrEMBL

Q923K6

Conserved Domains (4) summary

pfam00520
Location:1625 → 1882

Ion_trans; Ion transport protein

pfam03154
Location:2170 → 2429

Atrophin-1; Atrophin-1 family

pfam08763
Location:1955 → 2028

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1891 → 1944

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_039091011.2 → XP_038946939.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X4

UniProtKB/TrEMBL

F1LMS1

Conserved Domains (4) summary

pfam00520
Location:1621 → 1878

Ion_trans; Ion transport protein

pfam03154
Location:2166 → 2425

Atrophin-1; Atrophin-1 family

pfam08763
Location:1951 → 2024

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1887 → 1940

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_039091007.2 → XP_038946935.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

UniProtKB/TrEMBL

Q923K6

Conserved Domains (4) summary

pfam00520
Location:1625 → 1882

Ion_trans; Ion transport protein

pfam03154
Location:2170 → 2429

Atrophin-1; Atrophin-1 family

pfam08763
Location:1955 → 2028

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1891 → 1944

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_039091013.2 → XP_038946941.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X6

UniProtKB/TrEMBL

Q923K6

Conserved Domains (4) summary

pfam00520
Location:1606 → 1863

Ion_trans; Ion transport protein

pfam03154
Location:2151 → 2410

Atrophin-1; Atrophin-1 family

pfam08763
Location:1936 → 2009

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1872 → 1925

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017598908.3 → XP_017454397.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X3

UniProtKB/TrEMBL

Q923K6

Conserved Domains (5) summary

pfam00520
Location:1643 → 1882

Ion_trans; Ion transport protein

pfam05439
Location:487 → 520

JTB; Jumping translocation breakpoint protein (JTB)

pfam07816
Location:2201 → 2305

DUF1645; Protein of unknown function (DUF1645)

pfam08763
Location:1955 → 2029

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1890 → 1953

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_039091015.2 → XP_038946943.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X8

UniProtKB/TrEMBL

A0A8I5ZMA4

Conserved Domains (4) summary

pfam00520
Location:1595 → 1852

Ion_trans; Ion transport protein

pfam03154
Location:2140 → 2399

Atrophin-1; Atrophin-1 family

pfam08763
Location:1925 → 1998

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1861 → 1914

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017598911.3 → XP_017454400.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X7

UniProtKB/TrEMBL

Q923K6
XM_039091016.2 → XP_038946944.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X9

UniProtKB/TrEMBL

A0A0G2JVW2

Conserved Domains (4) summary

pfam00520
Location:1625 → 1882

Ion_trans; Ion transport protein

pfam03154
Location:2127 → 2386

Atrophin-1; Atrophin-1 family

pfam08763
Location:1955 → 2028

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1891 → 1944

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017598915.3 → XP_017454404.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X12

UniProtKB/TrEMBL

A0A0G2JVW2
XM_017598914.3 → XP_017454403.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X11

UniProtKB/TrEMBL

A0A0G2JVW2
XM_017598913.3 → XP_017454402.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X10

UniProtKB/TrEMBL

A0A0G2JVW2

Related

ENSRNOP00000077051.3, ENSRNOT00000108662.3
XM_039091017.2 → XP_038946945.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X13

UniProtKB/TrEMBL

Q923K6

Conserved Domains (4) summary

pfam00520
Location:1479 → 1736

Ion_trans; Ion transport protein

pfam03154
Location:2024 → 2283

Atrophin-1; Atrophin-1 family

pfam08763
Location:1809 → 1882

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1745 → 1798

GPHH; Voltage-dependent L-type calcium channel, IQ-associated