U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    sh2d5 SH2 domain containing 5 [ Danio rerio (zebrafish) ]

    Gene ID: 541529, updated on 17-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sh2d5provided by ZNC
    Official Full Name
    SH2 domain containing 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050327-67
    See related
    Ensembl:ENSDARG00000014324 AllianceGenome:ZFIN:ZDB-GENE-050327-67
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa11f09; wu:fa11f09; zgc:113447
    Summary
    Predicted to be active in postsynaptic density. Orthologous to human SH2D5 (SH2 domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See sh2d5 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (37638901..37650966)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (37371763..37383761)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:dkey-61o18.2 Neighboring gene heterochromatin protein 1, binding protein 3 Neighboring gene kinesin family member 17 Neighboring gene zgc:158258

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Spatio-temporal mRNA tracking in the early zebrafish embryo. Holler K, et al. Nat Commun, 2021 Jun 7. PMID 34099733, Free PMC Article
    2. Female Sex Development and Reproductive Duct Formation Depend on Wnt4a in Zebrafish. Kossack ME, et al. Genetics, 2019 Jan. PMID 30446521, Free PMC Article
    3. Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development. Zhu Z, et al. Front Genet, 2020. PMID 32296464, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    SH2 domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362556.1 → NP_001349485.1  SH2 domain-containing protein 5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BX005282
      UniProtKB/TrEMBL
      A0A8M2BGS5, F1Q5B0
      Related
      ENSDARP00000116139.1, ENSDART00000131782.3
      Conserved Domains (2) summary
      cd00173
      Location:288 → 363
      SH2; Src homology 2 (SH2) domain
      cd13157
      Location:25 → 152
      PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain

    2. NM_001362557.1 → NP_001349486.1  SH2 domain-containing protein 5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      BX005282
      UniProtKB/TrEMBL
      A0A8M2BGQ1
      Conserved Domains (2) summary
      cd00173
      Location:274 → 349
      SH2; Src homology 2 (SH2) domain
      cd13157
      Location:11 → 138
      PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain

    RNA

    1. NR_155759.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BX005282

    2. NR_155760.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses two alternate splice junctions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BX005282
      Related
      ENSDART00000003211.10

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      37638901..37650966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224165.1 → XP_068080266.1  SH2 domain-containing protein 5 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.