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    dbt dihydrolipoamide branched chain transacylase E2 [ Danio rerio (zebrafish) ]

    Gene ID: 541388, updated on 18-Sep-2024

    Summary

    Official Symbol
    dbtprovided by ZNC
    Official Full Name
    dihydrolipoamide branched chain transacylase E2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050320-85
    See related
    Ensembl:ENSDARG00000101561 AllianceGenome:ZFIN:ZDB-GENE-050320-85
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7147214; zgc:103768
    Summary
    Predicted to enable acetyltransferase activity and lipoic acid binding activity. Acts upstream of or within branched-chain amino acid metabolic process. Predicted to be active in mitochondrion. Is expressed in brain; gut; intestine; liver; and muscle. Used to study maple syrup urine disease. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human DBT (dihydrolipoamide branched chain transacylase E2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See dbt in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (16293164..16305821)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (16266894..16279551)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene U5 spliceosomal RNA Neighboring gene RNA 3'-terminal phosphate cyclase Neighboring gene dynein light chain Tctex-type 5 Neighboring gene leucine rich repeat containing 39 Neighboring gene tRNA methyltransferase 13 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipoic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within branched-chain amino acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
    Names
    que
    NP_001013533.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013515.1NP_001013533.1  lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

      See identical proteins and their annotated locations for NP_001013533.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090917
      UniProtKB/TrEMBL
      Q5BKV3
      Related
      ENSDARP00000137558.1, ENSDART00000170960.2
      Conserved Domains (4) summary
      cd06849
      Location:64137
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      PLN02528
      Location:66493
      PLN02528; 2-oxoisovalerate dehydrogenase E2 component
      pfam00198
      Location:278490
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
      pfam02817
      Location:174206
      E3_binding; e3 binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      16293164..16305821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395100.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      15..10969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)