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    KCNIP2 potassium voltage-gated channel interacting protein 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 540895, updated on 4-Oct-2024

    Summary

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    Official Symbol
    KCNIP2provided by VGNC
    Official Full Name
    potassium voltage-gated channel interacting protein 2provided by VGNC
    Primary source
    VGNC:VGNC:30451
    See related
    Ensembl:ENSBTAG00000016343
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See KCNIP2 in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (22551084..22569885, complement)

    Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene nucleophosmin/nucleoplasmin 3 Neighboring gene O-GlcNAcase Neighboring gene armadillo like helical domain containing 3 Neighboring gene HPS6 biogenesis of lysosomal organelles complex 2 subunit 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC155025

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables potassium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    A-type potassium channel modulatory protein KCNIP2; Kv channel-interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102250.1 → NP_001095720.1  A-type potassium channel modulatory protein KCNIP2

      See identical proteins and their annotated locations for NP_001095720.1

      Status: PROVISIONAL

      Source sequence(s)
      BC149230
      UniProtKB/TrEMBL
      A6QPA9, F1N410
      Conserved Domains (2) summary
      COG5126
      Location:38 → 204
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:89 → 151
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      22551084..22569885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005225595.5 → XP_005225652.1  Kv channel-interacting protein 2 isoform X2

      See identical proteins and their annotated locations for XP_005225652.1

      UniProtKB/TrEMBL
      F1N410
      Related
      ENSBTAP00000089314.1, ENSBTAT00000117569.1
      Conserved Domains (1) summary
      COG5126
      Location:93 → 259
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. XM_010819913.4 → XP_010818215.1  Kv channel-interacting protein 2 isoform X1

      Conserved Domains (2) summary
      COG5126
      Location:93 → 251
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:144 → 206
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. XM_005225605.5 → XP_005225662.1  Kv channel-interacting protein 2 isoform X7

      See identical proteins and their annotated locations for XP_005225662.1

      UniProtKB/TrEMBL
      A0AAA9RTR0
      Related
      ENSBTAP00000076431.1, ENSBTAT00000127376.1
      Conserved Domains (1) summary
      COG5126
      Location:108 → 274
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    4. XM_005225603.5 → XP_005225660.1  Kv channel-interacting protein 2 isoform X5

      UniProtKB/TrEMBL
      F1N410
      Conserved Domains (1) summary
      COG5126
      Location:43 → 201
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    5. XM_005225604.5 → XP_005225661.1  Kv channel-interacting protein 2 isoform X6

      See identical proteins and their annotated locations for XP_005225661.1

      UniProtKB/TrEMBL
      F1N410
      Related
      ENSBTAP00000021742.6, ENSBTAT00000021742.7
      Conserved Domains (1) summary
      COG5126
      Location:43 → 209
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    6. XM_005225600.5 → XP_005225657.1  Kv channel-interacting protein 2 isoform X3

      See identical proteins and their annotated locations for XP_005225657.1

      UniProtKB/TrEMBL
      A0AAA9S0U8
      Conserved Domains (1) summary
      COG5126
      Location:48 → 206
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    7. XM_005225601.5 → XP_005225658.1  Kv channel-interacting protein 2 isoform X4

      See identical proteins and their annotated locations for XP_005225658.1

      UniProtKB/TrEMBL
      A0AAA9SYI1, F1N410
      Related
      ENSBTAP00000090427.1, ENSBTAT00000092758.1
      Conserved Domains (1) summary
      COG5126
      Location:48 → 214
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    8. XM_005225599.5 → XP_005225656.1  Kv channel-interacting protein 2 isoform X8

      See identical proteins and their annotated locations for XP_005225656.1

      UniProtKB/TrEMBL
      A0AAA9SUU7, F1N410
      Related
      ENSBTAP00000087743.1, ENSBTAT00000112661.1
      Conserved Domains (1) summary
      COG5126
      Location:53 → 219
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version

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