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    SMAD9 SMAD family member 9 [ Bos taurus (domestic cattle) ]

    Gene ID: 540806, updated on 4-Oct-2024

    Summary

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    Official Symbol
    SMAD9provided by VGNC
    Official Full Name
    SMAD family member 9provided by VGNC
    Primary source
    VGNC:VGNC:34981
    See related
    BGD:BT12228; Ensembl:ENSBTAG00000007589
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SMAD9 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (24731849..24798689)

    Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene ALG5 dolichyl-phosphate beta-glucosyltransferase Neighboring gene uncharacterized LOC101906508 Neighboring gene protein SET-like Neighboring gene regulatory factor X associated protein Neighboring gene uncharacterized LOC112449127

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network. Nicklas D, et al. J R Soc Interface, 2013 Sep 6. PMID 23804438, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables I-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heteromeric SMAD protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mothers against decapentaplegic homolog 9
    Names
    MAD, mothers against decapentaplegic homolog 9
    mothers against DPP homolog 9
    NP_001070396.1
    XP_005213728.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076928.1 → NP_001070396.1  mothers against decapentaplegic homolog 9

      See identical proteins and their annotated locations for NP_001070396.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ922948
      UniProtKB/TrEMBL
      Q06AL5
      Related
      ENSBTAP00000047935.1, ENSBTAT00000055714.2
      Conserved Domains (2) summary
      cd10490
      Location:13 → 136
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cl00056
      Location:144 → 344
      MH2; C-terminal Mad Homology 2 (MH2) domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      24731849..24798689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005213671.5 → XP_005213728.1  mothers against decapentaplegic homolog 9 isoform X1

      See identical proteins and their annotated locations for XP_005213728.1

      UniProtKB/TrEMBL
      A0A3Q1N4I5, E1BG11
      Related
      ENSBTAP00000064737.1, ENSBTAT00000072620.2
      Conserved Domains (2) summary
      cd10490
      Location:13 → 136
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cl00056
      Location:230 → 430
      MH2; C-terminal Mad Homology 2 (MH2) domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials