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    ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 540568, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ATP2A2provided by VGNC
    Official Full Name
    ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2provided by VGNC
    Primary source
    VGNC:VGNC:26291
    See related
    Ensembl:ENSBTAG00000001398
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ATP2A2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (54211193..54268644)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 81 Neighboring gene transfer RNA aspartic acid (anticodon GUC) Neighboring gene uncharacterized LOC100300938 Neighboring gene anaphase promoting complex subunit 7 Neighboring gene microRNA mir-2285an Neighboring gene actin related protein 2/3 complex subunit 3 Neighboring gene GPN-loop GTPase 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The small GTPase RAB28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium. Ying G, et al. J Biol Chem, 2018 Nov 9. PMID 30228185, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle contraction by calcium ion signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sarcoplasmic/endoplasmic reticulum calcium ATPase 2
    Names
    ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
    NP_001178359.1
    XP_005217964.1
    XP_024833179.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191430.1 → NP_001178359.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2

      See identical proteins and their annotated locations for NP_001178359.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000017
      UniProtKB/TrEMBL
      A0AAA9T933, F1MPR3
      Related
      ENSBTAP00000001838.5, ENSBTAT00000001838.6
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 961
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:93 → 313
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:756 → 959
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:578 → 684
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:392 → 500
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      54211193..54268644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005217907.5 → XP_005217964.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LWF3, A0A3Q1M9U0
      Related
      ENSBTAP00000066955.2, ENSBTAT00000078158.2
      Conserved Domains (1) summary
      cd02083
      Location:5 → 988
      P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3

    2. XM_024977411.2 → XP_024833179.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SIU9, A0AAA9T933
      Related
      ENSBTAP00000083850.1, ENSBTAT00000089161.1
      Conserved Domains (1) summary
      cd02083
      Location:5 → 988
      P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials