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    METTL3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit [ Bos taurus (domestic cattle) ]

    Gene ID: 540339, updated on 4-Oct-2024

    Summary

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    Official Symbol
    METTL3provided by VGNC
    Official Full Name
    methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunitprovided by VGNC
    Primary source
    VGNC:VGNC:31412
    See related
    BGD:BT23751; Ensembl:ENSBTAG00000015148
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See METTL3 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (25662315..25677144)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL39-like Neighboring gene spalt like transcription factor 2 Neighboring gene TOX high mobility group box family member 4 Neighboring gene RAB2B, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC165887

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mRNA m(6)A methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N6-adenosine-methyltransferase catalytic subunit
    Names
    N6-adenosine-methyltransferase 70 kDa subunit
    methyltransferase like 3
    NP_001095708.1
    XP_024853529.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102238.2 → NP_001095708.1  N6-adenosine-methyltransferase catalytic subunit

      See identical proteins and their annotated locations for NP_001095708.1

      Status: PROVISIONAL

      Source sequence(s)
      BC150006
      UniProtKB/TrEMBL
      A6QQV4
      Related
      ENSBTAP00000020151.4, ENSBTAT00000020151.6
      Conserved Domains (1) summary
      pfam05063
      Location:389 → 550
      MT-A70; MT-A70

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      25662315..25677144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024997761.2 → XP_024853529.1  N6-adenosine-methyltransferase catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0AAA9SAL1
      Related
      ENSBTAP00000083126.1, ENSBTAT00000111008.1
      Conserved Domains (1) summary
      cl01947
      Location:389 → 512
      MT-A70
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials