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    PAK4 p21 (RAC1) activated kinase 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 539742, updated on 10-Oct-2024

    Summary

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    Gene symbol
    PAK4
    Gene description
    p21 (RAC1) activated kinase 4
    See related
    Ensembl:ENSBTAG00000013958
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PAK4 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (48852745..48900397)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene acid phosphatase 7, tartrate resistant (putative) Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene NCCRP1, F-box associated domain containing Neighboring gene syncollin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC138047

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 4
    Names
    p21(CDKN1A)-activated kinase 4
    p21-activated kinase 4
    NP_001069652.1
    XP_024834213.1
    XP_024834214.1
    XP_024834215.1
    XP_024834216.1
    XP_024834219.1
    XP_059732853.1
    XP_059732854.1
    XP_059732855.1
    XP_059732856.1
    XP_059732857.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076184.1 → NP_001069652.1  serine/threonine-protein kinase PAK 4

      See identical proteins and their annotated locations for NP_001069652.1

      Status: PROVISIONAL

      Source sequence(s)
      BC118110
      UniProtKB/TrEMBL
      A0AAF6DLY7, G5E5G9, Q17QZ0
      Conserved Domains (2) summary
      cd01093
      Location:10 → 48
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:302 → 593
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      48852745..48900397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059876873.1 → XP_059732856.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/TrEMBL
      G5E5G9, Q17QZ0

    2. XM_024978446.2 → XP_024834214.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/TrEMBL
      A0AAF6DLY7, G5E5G9, Q17QZ0
      Conserved Domains (2) summary
      cd01093
      Location:10 → 48
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:302 → 593
      PKc_like; Protein Kinases, catalytic domain

    3. XM_059876870.1 → XP_059732853.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/TrEMBL
      G5E5G9, Q17QZ0
      Related
      ENSBTAP00000018545.7, ENSBTAT00000018545.7

    4. XM_059876874.1 → XP_059732857.1  serine/threonine-protein kinase PAK 4 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MSB8
      Related
      ENSBTAP00000072888.2, ENSBTAT00000086158.2

    5. XM_024978448.2 → XP_024834216.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/TrEMBL
      A0AAF6DLY7, G5E5G9, Q17QZ0
      Conserved Domains (2) summary
      cd01093
      Location:10 → 48
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:302 → 593
      PKc_like; Protein Kinases, catalytic domain

    6. XM_059876872.1 → XP_059732855.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/TrEMBL
      G5E5G9, Q17QZ0

    7. XM_059876871.1 → XP_059732854.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/TrEMBL
      G5E5G9, Q17QZ0

    8. XM_024978445.2 → XP_024834213.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/TrEMBL
      A0AAF6DLY7, G5E5G9, Q17QZ0
      Conserved Domains (2) summary
      cd01093
      Location:10 → 48
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:302 → 593
      PKc_like; Protein Kinases, catalytic domain

    9. XM_024978451.2 → XP_024834219.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/TrEMBL
      A0AAF6DLY7, G5E5G9, Q17QZ0
      Conserved Domains (2) summary
      cd01093
      Location:10 → 48
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:302 → 593
      PKc_like; Protein Kinases, catalytic domain

    10. XM_024978447.2 → XP_024834215.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/TrEMBL
      A0AAF6DLY7, G5E5G9, Q17QZ0
      Conserved Domains (2) summary
      cd01093
      Location:10 → 48
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:302 → 593
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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