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    Ear7 eosinophil-associated, ribonuclease A family, member 7 [ Mus musculus (house mouse) ]

    Gene ID: 53873, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Ear7provided by MGI
    Official Full Name
    eosinophil-associated, ribonuclease A family, member 7provided by MGI
    Primary source
    MGI:MGI:1858205
    See related
    AllianceGenome:MGI:1858205
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mR7
    Summary
    Enables ribonuclease activity. Acts upstream of or within RNA metabolic process. Predicted to be located in secretory granule. [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    not in current annotation release
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    Genomic context

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    Location:
    chromosome: 14

    Bibliography

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    Related articles in PubMed

    1. Characterization of the divergent eosinophil ribonuclease, mEar 6, and its expression in response to Schistosoma mansoni infection in vivo. Nitto T, et al. Genes Immun, 2004 Dec. PMID 15526002
    2. Mouse eosinophil associated ribonucleases: Mechanism of cytotoxic, antibacterial and antiparasitic activities. Attery A, et al. Int J Biol Macromol, 2017 Jan. PMID 27765572
    3. Mouse eosinophil-associated ribonucleases: a unique subfamily expressed during hematopoiesis. Cormier SA, et al. Mamm Genome, 2001 May. PMID 11331942
    4. Two highly homologous ribonuclease genes expressed in mouse eosinophils identify a larger subgroup of the mammalian ribonuclease superfamily. Larson KA, et al. Proc Natl Acad Sci U S A, 1996 Oct 29. PMID 8901588, Free PMC Article
    5. Rapid evolution of the ribonuclease A superfamily: adaptive expansion of independent gene clusters in rats and mice. Singhania NA, et al. J Mol Evol, 1999 Dec. PMID 10594173

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional activity of four mouse eosinophil associated ribonucleases, mEAR2, mEAR5, mEAR7 and mEAR11.
      Title: Mouse eosinophil associated ribonucleases: Mechanism of cytotoxic, antibacterial and antiparasitic activities.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA nuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in secretory granule TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eosinophil-associated, ribonuclease A family, member 7
    Names
    eosinophil-associated ribonuclease 7
    murine ribonuclease 7
    NP_059081.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017385.1 → NP_059081.1  eosinophil-associated, ribonuclease A family, member 7 precursor

      See identical proteins and their annotated locations for NP_059081.1

      Status: PROVISIONAL

      Source sequence(s)
      AY324806
      UniProtKB/TrEMBL
      Q9R126
      Conserved Domains (1) summary
      pfam00074
      Location:30 → 152
      RnaseA; Pancreatic ribonuclease
    Nucleotide Protein Strain
    Heading Accession and Version

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