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    SESN1 sestrin 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 538226, updated on 4-Oct-2024

    Summary

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    Official Symbol
    SESN1provided by VGNC
    Official Full Name
    sestrin 1provided by VGNC
    Primary source
    VGNC:VGNC:34488
    See related
    BGD:BT10754; Ensembl:ENSBTAG00000003015
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SESN1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (41069131..41183445)

    Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene putative uncharacterized protein C6orf183 Neighboring gene centrosomal protein 57 like 1 Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene armadillo repeat containing 2 Neighboring gene transfer RNA phenylalanine (anticodon GAA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-leucine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on peroxide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to L-leucine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to leucine starvation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sestrin-1
    NP_001094644.1
    XP_005210866.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101174.1 → NP_001094644.1  sestrin-1

      See identical proteins and their annotated locations for NP_001094644.1

      Status: PROVISIONAL

      Source sequence(s)
      BC149973
      UniProtKB/TrEMBL
      A6QQS4
      Related
      ENSBTAP00000003925.4, ENSBTAT00000003925.5
      Conserved Domains (1) summary
      pfam04636
      Location:47 → 491
      PA26; PA26 p53-induced protein (sestrin)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      41069131..41183445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005210809.4 → XP_005210866.1  sestrin-1 isoform X1

      See identical proteins and their annotated locations for XP_005210866.1

      UniProtKB/TrEMBL
      A7MBI2
      Conserved Domains (1) summary
      pfam04636
      Location:106 → 550
      PA26; PA26 p53-induced protein (sestrin)
    Nucleotide Protein Strain
    Heading Accession and Version

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