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    CYLD CYLD lysine 63 deubiquitinase [ Bos taurus (domestic cattle) ]

    Gene ID: 536421, updated on 12-Oct-2024

    Summary

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    Official Symbol
    CYLDprovided by VGNC
    Official Full Name
    CYLD lysine 63 deubiquitinaseprovided by VGNC
    Primary source
    VGNC:VGNC:49141
    See related
    BGD:BT24926; Ensembl:ENSBTAG00000006291
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CYLD in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (19131356..19204356)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132342802 Neighboring gene sorting nexin 20 Neighboring gene nucleotide binding oligomerization domain containing 2 Neighboring gene uncharacterized LOC132342801 Neighboring gene uncharacterized LOC101906490 Neighboring gene spalt like transcription factor 1 Neighboring gene uncharacterized LOC132342803

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC137952

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in necroptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein K63-linked deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase CYLD
    Names
    deubiquitinating enzyme CYLD
    probable ubiquitin carboxyl-terminal hydrolase CYLD
    ubiquitin thioesterase CYLD
    ubiquitin thiolesterase CYLD
    ubiquitin-specific-processing protease CYLD
    NP_001039882.1
    XP_005218741.1
    XP_015331249.1
    XP_015331250.1
    XP_024834167.1
    XP_024834168.1
    XP_024834171.1
    XP_059732819.1
    XP_059732820.1
    XP_059732821.1
    XP_059732822.1
    XP_059732823.1
    XP_059732824.1
    XP_059732825.1
    XP_059732826.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046417.1 → NP_001039882.1  ubiquitin carboxyl-terminal hydrolase CYLD

      See identical proteins and their annotated locations for NP_001039882.1

      Status: PROVISIONAL

      Source sequence(s)
      BC114710
      UniProtKB/Swiss-Prot
      Q1RMU2
      UniProtKB/TrEMBL
      A0A3Q1LMF5
      Related
      ENSBTAP00000008257.4, ENSBTAT00000008257.5
      Conserved Domains (3) summary
      smart01052
      Location:469 → 537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590 → 945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304 → 468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      19131356..19204356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059876837.1 → XP_059732820.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      UniProtKB/Swiss-Prot
      Q1RMU2

    2. XM_059876836.1 → XP_059732819.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      UniProtKB/Swiss-Prot
      Q1RMU2

    3. XM_024978399.2 → XP_024834167.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      UniProtKB/Swiss-Prot
      Q1RMU2
      UniProtKB/TrEMBL
      A0A3Q1LMF5
      Conserved Domains (3) summary
      smart01052
      Location:469 → 537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590 → 945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304 → 468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured

    4. XM_059876838.1 → XP_059732821.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      UniProtKB/Swiss-Prot
      Q1RMU2

    5. XM_005218684.4 → XP_005218741.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_005218741.1

      UniProtKB/Swiss-Prot
      Q1RMU2
      UniProtKB/TrEMBL
      A0A3Q1LMF5
      Conserved Domains (3) summary
      smart01052
      Location:469 → 537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590 → 945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304 → 468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured

    6. XM_059876841.1 → XP_059732824.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X6

    7. XM_024978400.2 → XP_024834168.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      UniProtKB/Swiss-Prot
      Q1RMU2
      UniProtKB/TrEMBL
      A0A3Q1LMF5
      Conserved Domains (3) summary
      smart01052
      Location:469 → 537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590 → 945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304 → 468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured

    8. XM_015475763.3 → XP_015331249.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

      UniProtKB/TrEMBL
      A0A3Q1LJF5, A0A3Q1LMF5
      Conserved Domains (3) summary
      smart01052
      Location:397 → 465
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:518 → 873
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:305 → 396
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured

    9. XM_024978403.2 → XP_024834171.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

      UniProtKB/TrEMBL
      A0A3Q1LJF5, A0A3Q1LMF5
      Related
      ENSBTAP00000059534.1, ENSBTAT00000082885.2
      Conserved Domains (3) summary
      smart01052
      Location:397 → 465
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:518 → 873
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:305 → 396
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured

    10. XM_059876842.1 → XP_059732825.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X6

    11. XM_059876840.1 → XP_059732823.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X3

      UniProtKB/TrEMBL
      A0AAA9TL72
      Related
      ENSBTAP00000099177.1, ENSBTAT00000129451.1

    12. XM_059876839.1 → XP_059732822.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    13. XM_015475764.3 → XP_015331250.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X5

      UniProtKB/TrEMBL
      A0A3Q1LMF5
      Conserved Domains (3) summary
      smart01052
      Location:313 → 381
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:434 → 789
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:148 → 312
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured

    14. XM_059876843.1 → XP_059732826.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1RMU2.1 GenPept UniProtKB/Swiss-Prot:Q1RMU2

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