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    B3gnt2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 53625, updated on 2-Nov-2024

    Summary

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    Official Symbol
    B3gnt2provided by MGI
    Official Full Name
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2provided by MGI
    Primary source
    MGI:MGI:1889505
    See related
    Ensembl:ENSMUSG00000051650 AllianceGenome:MGI:1889505
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BGnT1; BGnT2; B3gnt1; BGnT-1; BGnT-2; B3Galt6; Beta3gnt
    Summary
    Predicted to enable N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; protein glycosylation; and sensory perception of smell. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and nose. Orthologous to human B3GNT2 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 23.2), colon adult (RPKM 14.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See B3gnt2 in Genome Data Viewer
    Location:
    11 A3.2; 11 14.22 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (22784739..22810336, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (22834739..22860336, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8389 Neighboring gene methionine aminopeptidase 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28885 Neighboring gene STARR-positive B cell enhancer ABC_E6962 Neighboring gene ribosomal protein S16 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:22715949-22716150 Neighboring gene STARR-seq mESC enhancer starr_28889 Neighboring gene STARR-seq mESC enhancer starr_28890 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:22753904-22754057 Neighboring gene predicted gene, 24917 Neighboring gene STARR-seq mESC enhancer starr_28892 Neighboring gene COMM domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3935 Neighboring gene STARR-seq mESC enhancer starr_28894 Neighboring gene zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance. Knott TK, et al. Neural Dev, 2012 Jul 4. PMID 22559903, Free PMC Article
    2. Beta3GnT2 (B3GNT2), a major polylactosamine synthase: analysis of B3GNT2-deficient mice. Togayachi A, et al. Methods Enzymol, 2010. PMID 20816167
    3. Molecular cloning and expression analysis of a mouse UDP-GlcNAc:Gal(beta1-4)Glc(NAc)-R beta1,3-N-acetylglucosaminyltransferase homologous to Drosophila melanogaster Brainiac and the beta1,3-galactosyltransferase family. Egan S, et al. Glycoconj J, 2000 Dec. PMID 11511811
    4. Polylactosamine on glycoproteins influences basal levels of lymphocyte and macrophage activation. Togayachi A, et al. Proc Natl Acad Sci U S A, 2007 Oct 2. PMID 17890318, Free PMC Article
    5. Lactosamine modulates the rate of migration of GnRH neurons during mouse development. Bless E, et al. Eur J Neurosci, 2006 Aug. PMID 16930397

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data clearly suggest that GCNT2 functions in vivo together with beta3GnT2 to determine poly-N-acetyllactosamine (PLN) levels in olfactory neurons by regulating beta1,6-branches that promote PLN extension.
      Title: N-linked polylactosamine glycan synthesis is regulated by co-expression of β3GnT2 and GCNT2.
    2. These results identify a novel function for beta3GnT2 glycosylation in maintaining expression of layer-specific vomeronasal receptors
      Title: β3GnT2 null mice exhibit defective accessory olfactory bulb innervation.
    3. Beta3GnT2(-/-) mice exhibit a relatively small deficit in their ability to discriminate divergent odors.
      Title: Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance.
    4. The results suggested taht beta3GnT2 maintains adenylyl cyclase-3 signaling and axon guidance molecule expression in the olfactory epithelium.
      Title: β3GnT2 maintains adenylyl cyclase-3 signaling and axon guidance molecule expression in the olfactory epithelium.
    5. In beta1,3-N-acetylglucosaminyltransferase (B3gnt2) B3gnt2-deficient (B3gnt2-/-) mice, the number of polylactosamine structures was markedly lower than in wild-type mice
      Title: Beta3GnT2 (B3GNT2), a major polylactosamine synthase: analysis of B3GNT2-deficient mice.
    6. up-regulation of beta3Gn-T8 in differentiated cells increases poly-N-acetyllactosamine chains by activating intrinsic beta3Gn-T2.
      Title: Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in poly-N-acetyllactosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly-N-acetyllactosamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in poly-N-acetyllactosamine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
    Names
    UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 6
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
    beta-1,3-Gn-T1
    beta-1,3-Gn-T2
    beta-1,3-N-acetylglucosaminyltransferase 1
    beta-1,3-N-acetylglucosaminyltransferase 2
    beta3Gn-T1
    beta3Gn-T2
    NP_001162585.1
    NP_058584.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169114.1 → NP_001162585.1  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

      See identical proteins and their annotated locations for NP_001162585.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different exon for its 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL772364
      Consensus CDS
      CCDS24471.1
      UniProtKB/Swiss-Prot
      Q91V18, Q9Z222
      UniProtKB/TrEMBL
      Q3TVJ9
      Related
      ENSMUSP00000053528.4, ENSMUST00000055549.4
      Conserved Domains (1) summary
      cl21608
      Location:156 → 345
      Galactosyl_T; Galactosyltransferase

    2. NM_016888.5 → NP_058584.3  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

      See identical proteins and their annotated locations for NP_058584.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL772364
      Consensus CDS
      CCDS24471.1
      UniProtKB/Swiss-Prot
      Q91V18, Q9Z222
      UniProtKB/TrEMBL
      Q3TVJ9
      Related
      ENSMUSP00000060247.11, ENSMUST00000062844.11
      Conserved Domains (1) summary
      cl21608
      Location:156 → 345
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      22784739..22810336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z222.3 GenPept UniProtKB/Swiss-Prot:Q9Z222

    Gene LinkOut

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