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    SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 535439, updated on 10-Oct-2024

    Summary

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    Official Symbol
    SMARCA1provided by VGNC
    Official Full Name
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1provided by VGNC
    Primary source
    VGNC:VGNC:34985
    See related
    Ensembl:ENSBTAG00000002292
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SMARCA1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (13491460..13564454, complement)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132344363 Neighboring gene transfer RNA arginine (anticodon ACG) Neighboring gene uncharacterized LOC104970471 Neighboring gene small nucleolar RNA SNORD112 Neighboring gene OCRL inositol polyphosphate-5-phosphatase Neighboring gene microRNA mir-12048 Neighboring gene apelin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nucleosome binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleosome organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable global transcription activator SNF2L1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191542.1 → NP_001178471.1  probable global transcription activator SNF2L1

      Status: VALIDATED

      Source sequence(s)
      BG691348, DV812296, EE349465, EV698714, EV719861, EW683817, GH310161, GH326834
      UniProtKB/TrEMBL
      A0A3Q1LZX5
      Conserved Domains (8) summary
      smart00717
      Location:860 → 901
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00046
      Location:206 → 345
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00167
      Location:862 → 901
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00176
      Location:189 → 469
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:488 → 615
      Helicase_C; Helicase conserved C-terminal domain
      pfam09110
      Location:761 → 841
      HAND; HAND
      pfam09111
      Location:916 → 1028
      SLIDE; SLIDE
      pfam13892
      Location:87 → 113
      DBINO; DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      13491460..13564454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005227494.5 → XP_005227551.1  probable global transcription activator SNF2L1 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LZX5, A0AAA9T616
      Related
      ENSBTAP00000091212.1, ENSBTAT00000121064.1
      Conserved Domains (7) summary
      PLN03142
      Location:90 → 1060
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd00046
      Location:206 → 345
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00167
      Location:850 → 889
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00271
      Location:488 → 603
      Helicase_C; Helicase conserved C-terminal domain
      pfam09110
      Location:749 → 829
      HAND; HAND
      pfam09111
      Location:904 → 1016
      SLIDE; SLIDE
      pfam13892
      Location:87 → 113
      DBINO; DNA-binding domain

    2. XM_059883485.1 → XP_059739468.1  probable global transcription activator SNF2L1 isoform X4

    3. XM_005227493.5 → XP_005227550.1  probable global transcription activator SNF2L1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LZX5
      Related
      ENSBTAP00000093980.1, ENSBTAT00000131353.1
      Conserved Domains (7) summary
      PLN03142
      Location:90 → 1072
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd00046
      Location:206 → 345
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00167
      Location:862 → 901
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00271
      Location:488 → 615
      Helicase_C; Helicase conserved C-terminal domain
      pfam09110
      Location:761 → 841
      HAND; HAND
      pfam09111
      Location:916 → 1028
      SLIDE; SLIDE
      pfam13892
      Location:87 → 113
      DBINO; DNA-binding domain

    4. XM_005227495.5 → XP_005227552.1  probable global transcription activator SNF2L1 isoform X3

      See identical proteins and their annotated locations for XP_005227552.1

      UniProtKB/TrEMBL
      A0A3Q1LZX5
      Conserved Domains (8) summary
      smart00717
      Location:860 → 901
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00046
      Location:206 → 345
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00167
      Location:862 → 901
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00176
      Location:189 → 469
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:488 → 615
      Helicase_C; Helicase conserved C-terminal domain
      pfam09110
      Location:761 → 841
      HAND; HAND
      pfam09111
      Location:916 → 1028
      SLIDE; SLIDE
      pfam13892
      Location:87 → 113
      DBINO; DNA-binding domain

    5. XM_005227496.5 → XP_005227553.1  probable global transcription activator SNF2L1 isoform X3

      See identical proteins and their annotated locations for XP_005227553.1

      UniProtKB/TrEMBL
      A0A3Q1LZX5
      Related
      ENSBTAP00000061286.2, ENSBTAT00000082702.2
      Conserved Domains (8) summary
      smart00717
      Location:860 → 901
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00046
      Location:206 → 345
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00167
      Location:862 → 901
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00176
      Location:189 → 469
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:488 → 615
      Helicase_C; Helicase conserved C-terminal domain
      pfam09110
      Location:761 → 841
      HAND; HAND
      pfam09111
      Location:916 → 1028
      SLIDE; SLIDE
      pfam13892
      Location:87 → 113
      DBINO; DNA-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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