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    PIAS3 protein inhibitor of activated STAT 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 535312, updated on 4-Oct-2024

    Summary

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    Official Symbol
    PIAS3provided by VGNC
    Official Full Name
    protein inhibitor of activated STAT 3provided by VGNC
    Primary source
    VGNC:VGNC:32857
    See related
    BGD:BT11922; Ensembl:ENSBTAG00000021634
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PIAS3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (21505075..21532629)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha 10 Neighboring gene ankyrin repeat domain 35 Neighboring gene nudix hydrolase 17 Neighboring gene RNA polymerase III subunit C Neighboring gene ring finger protein 115 Neighboring gene CD160 molecule

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC165870

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables SUMO ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 SUMO-protein ligase PIAS3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102185.1 → NP_001095655.1  E3 SUMO-protein ligase PIAS3

      See identical proteins and their annotated locations for NP_001095655.1

      Status: PROVISIONAL

      Source sequence(s)
      BC150000
      UniProtKB/TrEMBL
      A0A3Q1LMC0, A6QQU9
      Related
      ENSBTAP00000028829.5, ENSBTAT00000028829.6
      Conserved Domains (2) summary
      pfam14324
      Location:128 → 272
      PINIT; PINIT domain
      cd16790
      Location:324 → 371
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      21505075..21532629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005203991.5 → XP_005204048.1  E3 SUMO-protein ligase PIAS3 isoform X2

      See identical proteins and their annotated locations for XP_005204048.1

      UniProtKB/TrEMBL
      F6PT61
      Conserved Domains (3) summary
      cd16790
      Location:315 → 362
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:119 → 268
      PINIT; PINIT domain
      cl02640
      Location:2 → 27
      SAP; SAP domain

    2. XM_010803096.4 → XP_010801398.1  E3 SUMO-protein ligase PIAS3 isoform X1

      UniProtKB/TrEMBL
      F6PT61
      Conserved Domains (2) summary
      pfam14324
      Location:128 → 272
      PINIT; PINIT domain
      cd16790
      Location:324 → 371
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

    3. XM_024989510.2 → XP_024845278.1  E3 SUMO-protein ligase PIAS3 isoform X2

      UniProtKB/TrEMBL
      F6PT61
      Conserved Domains (3) summary
      cd16790
      Location:315 → 362
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:119 → 268
      PINIT; PINIT domain
      cl02640
      Location:2 → 27
      SAP; SAP domain

    RNA

    1. XR_009493798.1 RNA Sequence

    2. XR_009493799.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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