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    HGTX HGTX [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53446, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HGTXprovided by FlyBase
    Official Full Name
    HGTXprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040318
    Locus tag
    Dmel_CG13475
    See related
    AllianceGenome:FB:FBgn0040318
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13475; CG4745; Dmel\CG13475; dNkx6; Nk6; nkx6; Nkx6
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and DNA-binding transcription factor binding activity. Involved in negative regulation of gene expression; nervous system development; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; ectoderm; embryonic/larval nervous system; extended germ band embryo; and neuroblast of ventral nervous system. Used to study obesity. Human ortholog(s) of this gene implicated in spastic ataxia 8. Orthologous to several human genes including NKX6-2 (NK6 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See HGTX in Genome Data Viewer
    Location:
    70E3-70E3; 3-42 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14583222..14599540, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14576322..14592640, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44843 Neighboring gene uncharacterized protein Neighboring gene Leucokinin Neighboring gene uncharacterized protein Neighboring gene shade Neighboring gene uncharacterized protein Neighboring gene RecQ5 helicase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Nkx6 homeodomain protein has both activation and repression domains and can activate target gene expression. Syu LJ, et al. Brain Res, 2009 Apr 17. PMID 19232326
    2. A novel temporal identity window generates alternating Eve(+)/Nkx6(+) motor neuron subtypes in a single progenitor lineage. Seroka A, et al. Neural Dev, 2020 Jul 28. PMID 32723364, Free PMC Article
    3. Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism. Valsesia A, et al. Nat Commun, 2019 Feb 1. PMID 30710084, Free PMC Article
    4. The homeodomain transcription factor Hb9 controls axon guidance in Drosophila through the regulation of Robo receptors. Santiago C, et al. Cell Rep, 2014 Apr 10. PMID 24685136, Free PMC Article
    5. Crossing the border: molecular control of motor axon exit. Bravo-Ambrosio A, et al. Int J Mol Sci, 2011. PMID 22272090, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel temporal identity window generates alternating Eve(+)/Nkx6(+) motor neuron subtypes in a single progenitor lineage.
      Title: A novel temporal identity window generates alternating Eve(+)/Nkx6(+) motor neuron subtypes in a single progenitor lineage.
    2. These results indicate that the anteroposterior patterning gene ems controls the expression of DV genes, and vice versa.
      Title: Ems and Nkx6 are central regulators in dorsoventral patterning of the Drosophila brain.
    3. Nkx6 protein has both activation & repression domains; over-expression of Nkx6 results in an increase in the number of Fascilin II expressing motor neurons in the intersegmental nerve B branch
      Title: The Drosophila Nkx6 homeodomain protein has both activation and repression domains and can activate target gene expression.
    4. Nkx6 acts in a specific neuronal population to link neuronal subtype identity to neuronal morphology and connectivity
      Title: Drosophila homeodomain protein Nkx6 coordinates motoneuron subtype identity and axonogenesis.
    5. In vnd mutants, head neuroectoderm Nk6 expression is abolished where it is normally co-expressed with vnd.
      Title: Nk6, a novel Drosophila homeobox gene regulated by vnd.
    6. Overexpression of fish or fly Nkx6 is sufficient to generate supernumerary motoneurons in both zebrafish and flies
      Title: Zebrafish and fly Nkx6 proteins have similar CNS expression patterns and regulate motoneuron formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    HGTX
    Names
    CG13475-PA
    CG13475-PC
    HGTX-PA
    HGTX-PC
    Nk6 homeobox
    NP_001368954.1
    • non-AUG (AAG) translation initiation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14583222..14599540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382022.1 → NP_001368954.1  HGTX, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6J3T5M5, Q8SXK1
      Conserved Domains (2) summary
      COG5422
      Location:179 → 388
      ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
      pfam00046
      Location:469 → 523
      Homeobox; Homeobox domain

    2. NM_144357.3 → NP_652614.1  HGTX, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXK1, Q9NHP8, Q9VUF6
      Related
      FBpp0075463
      Conserved Domains (1) summary
      pfam00046
      Location:395 → 448
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6J3T5M5 A0A6J3T5M5
    Q8SXK1 Q8SXK1
    Q9NHP8 Q9NHP8

    Gene LinkOut

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