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    NR1D2 nuclear receptor subfamily 1 group D member 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 532076, updated on 4-Oct-2024

    Summary

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    Official Symbol
    NR1D2provided by VGNC
    Official Full Name
    nuclear receptor subfamily 1 group D member 2provided by VGNC
    Primary source
    VGNC:VGNC:32229
    See related
    BGD:BT13154; Ensembl:ENSBTAG00000018024
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Summary
    This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. [provided by RefSeq, Feb 2014]
    Orthologs
    human mouse all
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    Genomic context

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    See NR1D2 in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (41985187..42013956, complement)

    Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor beta Neighboring gene uncharacterized LOC132344077 Neighboring gene uncharacterized LOC112444600 Neighboring gene uncharacterized LOC132344078 Neighboring gene transfer RNA arginine (anticodon CCG) Neighboring gene ribosomal protein L15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in retinoic acid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear receptor subfamily 1 group D member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289793.1 → NP_001276722.1  nuclear receptor subfamily 1 group D member 2

      See identical proteins and their annotated locations for NP_001276722.1

      Status: INFERRED

      Source sequence(s)
      GJ062955
      Conserved Domains (2) summary
      cd06940
      Location:395 → 583
      NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily
      cd07166
      Location:105 → 193
      NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      41985187..42013956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024986287.2 → XP_024842055.1  nuclear receptor subfamily 1 group D member 2 isoform X2

      UniProtKB/TrEMBL
      F1MWI2
      Related
      ENSBTAP00000023994.6, ENSBTAT00000023994.7
      Conserved Domains (2) summary
      cd06940
      Location:388 → 576
      NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily
      cd07166
      Location:98 → 186
      NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers

    2. XM_059882242.1 → XP_059738225.1  nuclear receptor subfamily 1 group D member 2 isoform X3

    3. XM_059882241.1 → XP_059738224.1  nuclear receptor subfamily 1 group D member 2 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TZE7
      Related
      ENSBTAP00000103689.1, ENSBTAT00000127335.1
    Nucleotide Protein Strain
    Heading Accession and Version

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    Molecular Biology Databases
    Research Materials