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    WNT5A Wnt family member 5A [ Bos taurus (domestic cattle) ]

    Gene ID: 530005, updated on 4-Oct-2024

    Summary

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    Official Symbol
    WNT5Aprovided by VGNC
    Official Full Name
    Wnt family member 5Aprovided by VGNC
    Primary source
    VGNC:VGNC:36960
    See related
    BGD:BT11096; Ensembl:ENSBTAG00000020221
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See WNT5A in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (45540765..45559683)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix protein 3-like Neighboring gene ELKS/RAB6-interacting/CAST family member 2 Neighboring gene uncharacterized LOC132343510 Neighboring gene uncharacterized LOC104975559 Neighboring gene uncharacterized LOC112443470 Neighboring gene uncharacterized LOC132343511

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-canonical WNT5A is a potential regulator of granulosa cell function in cattle. Abedini A, et al. Mol Cell Endocrinol, 2015 Mar 5. PMID 25600632
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WNT5A is a negative regulator of FSH-stimulated granulosa cell steroidogenesis in cattle.
      Title: Non-canonical WNT5A is a potential regulator of granulosa cell function in cattle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables frizzled binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein Wnt-5a
    Names
    wingless-type MMTV integration site family, member 5A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205971.1 → NP_001192900.1  protein Wnt-5a

      See identical proteins and their annotated locations for NP_001192900.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000022
      UniProtKB/TrEMBL
      E1BDG5
      Related
      ENSBTAP00000026930.4, ENSBTAT00000026930.6
      Conserved Domains (1) summary
      cd19347
      Location:69 → 380
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      45540765..45559683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005222857.5 → XP_005222914.1  protein Wnt-5a isoform X1

      See identical proteins and their annotated locations for XP_005222914.1

      Conserved Domains (1) summary
      cd19347
      Location:49 → 360
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

    2. XM_005222855.5 → XP_005222912.1  protein Wnt-5a isoform X1

      See identical proteins and their annotated locations for XP_005222912.1

      Conserved Domains (1) summary
      cd19347
      Location:49 → 360
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

    3. XM_005222858.5 → XP_005222915.1  protein Wnt-5a isoform X1

      See identical proteins and their annotated locations for XP_005222915.1

      Conserved Domains (1) summary
      cd19347
      Location:49 → 360
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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