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    LRCH4 leucine rich repeats and calponin homology domain containing 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 527134, updated on 4-Oct-2024

    Summary

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    Official Symbol
    LRCH4provided by VGNC
    Official Full Name
    leucine rich repeats and calponin homology domain containing 4provided by VGNC
    Primary source
    VGNC:VGNC:30974
    See related
    BGD:BT20449; Ensembl:ENSBTAG00000003160
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See LRCH4 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (35971602..35982277)

    Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene procollagen C-endopeptidase enhancer Neighboring gene F-box protein 24 Neighboring gene Sin3A associated protein 25 Neighboring gene insulin receptor substrate 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC140386

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine-rich repeat and calponin homology domain-containing protein 4
    Names
    leucine-rich repeats and calponin homology (CH) domain containing 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083450.1 → NP_001076919.1  leucine-rich repeat and calponin homology domain-containing protein 4

      See identical proteins and their annotated locations for NP_001076919.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133495
      UniProtKB/TrEMBL
      A0AAA9SFQ4, A3KN20
      Conserved Domains (5) summary
      cd00116
      Location:103 → 245
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:46 → 69
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00307
      Location:543 → 636
      CH; Calponin homology (CH) domain
      pfam12799
      Location:92 → 131
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:182 → 239
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      35971602..35982277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024984925.2 → XP_024840693.1  leucine-rich repeat and calponin homology domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LXU2, A0AAA9SFQ4
      Related
      ENSBTAP00000062042.1, ENSBTAT00000074286.2
      Conserved Domains (4) summary
      smart00033
      Location:564 → 636
      CH; Calponin homology domain
      COG4886
      Location:74 → 255
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:46 → 69
      LRR_RI; leucine-rich repeat [structural motif]
      cl27000
      Location:331 → 513
      TFIIFa; Transcription initiation factor IIF, alpha subunit, N-terminal region of RAP74. Subunit of transcription initiation complex involved in initiation, elongation and promoter escape.Tetramer of 2 alpha and 2 beta TFIIF subunits interacts directly with RNA ...

    2. XM_024984926.2 → XP_024840694.1  leucine-rich repeat and calponin homology domain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      A0AAA9SFQ4, F1MV58
      Related
      ENSBTAP00000037062.5, ENSBTAT00000037224.5
      Conserved Domains (4) summary
      smart00033
      Location:541 → 613
      CH; Calponin homology domain
      COG4886
      Location:74 → 255
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:46 → 69
      LRR_RI; leucine-rich repeat [structural motif]
      cl26386
      Location:373 → 487
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    Nucleotide Protein Strain
    Heading Accession and Version

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