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    DVL1 dishevelled segment polarity protein 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 523325, updated on 4-Oct-2024

    Summary

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    Gene symbol
    DVL1
    Gene description
    dishevelled segment polarity protein 1
    See related
    BGD:BT13254; Ensembl:ENSBTAG00000010696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DVL1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (51179926..51192053)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene aurora kinase A interacting protein 1 Neighboring gene matrix remodeling associated 8 Neighboring gene taste 1 receptor member 3 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene integrator complex subunit 11 Neighboring gene pseudouridine synthase like 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables frizzled binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    segment polarity protein dishevelled homolog DVL-1
    Names
    dishevelled, dsh homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206601.1 → NP_001193530.1  segment polarity protein dishevelled homolog DVL-1

      Status: VALIDATED

      Source sequence(s)
      BC154382, NKLS02000016
      UniProtKB/TrEMBL
      A8KC70, F1N6M9
      Related
      ENSBTAP00000014152.6, ENSBTAT00000014152.7
      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd04438
      Location:417 → 499
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam00595
      Location:251 → 336
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02377
      Location:90 → 247
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:503 → 690
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      51179926..51192053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024976247.2 → XP_024832015.1  segment polarity protein dishevelled homolog DVL-1 isoform X1

      UniProtKB/TrEMBL
      A8KC70
      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd04438
      Location:417 → 499
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam00595
      Location:251 → 336
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02377
      Location:90 → 247
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:533 → 719
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    2. XM_024976251.2 → XP_024832019.1  segment polarity protein dishevelled homolog DVL-1 isoform X4

      UniProtKB/TrEMBL
      A8KC70
      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd04438
      Location:392 → 474
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam00595
      Location:251 → 336
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02377
      Location:90 → 247
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:508 → 694
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    3. XM_024976255.2 → XP_024832023.1  segment polarity protein dishevelled homolog DVL-1 isoform X6

      UniProtKB/TrEMBL
      A8KC70
      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd04438
      Location:392 → 474
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam00595
      Location:251 → 336
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02377
      Location:90 → 247
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:478 → 665
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    4. XM_024976248.2 → XP_024832016.1  segment polarity protein dishevelled homolog DVL-1 isoform X2

      UniProtKB/TrEMBL
      A8KC70
      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd04438
      Location:416 → 498
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam00595
      Location:250 → 335
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02377
      Location:90 → 246
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:532 → 718
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    5. XM_024976249.2 → XP_024832017.1  segment polarity protein dishevelled homolog DVL-1 isoform X3

      UniProtKB/TrEMBL
      A8KC70
      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd04438
      Location:411 → 493
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam00595
      Location:245 → 330
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02377
      Location:90 → 241
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:527 → 713
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    6. XM_024976257.2 → XP_024832025.1  segment polarity protein dishevelled homolog DVL-1 isoform X8

      UniProtKB/TrEMBL
      A8KC70
      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd04438
      Location:417 → 499
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam00595
      Location:251 → 336
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02377
      Location:90 → 247
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:503 → 571
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    7. XM_024976254.2 → XP_024832022.1  segment polarity protein dishevelled homolog DVL-1 isoform X5

      Conserved Domains (4) summary
      cd04438
      Location:364 → 446
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam00595
      Location:198 → 283
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02377
      Location:94 → 194
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:480 → 666
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    8. XM_024976256.2 → XP_024832024.1  segment polarity protein dishevelled homolog DVL-1 isoform X7

      Conserved Domains (4) summary
      cd04438
      Location:358 → 440
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam00595
      Location:192 → 277
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02377
      Location:88 → 188
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:474 → 660
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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