PREX2 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PREX2provided by VGNC
Official Full Name: phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2provided by VGNC
Primary source: VGNC:VGNC:33312
See related: BGD:BT13634; Ensembl:ENSBTAG00000022169
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: DEPDC2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	14	NC_037341.1 (31977378..32276071)

Chromosome 14 - NC_037341.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

Names: DEP domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001192526.2 → NP_001179455.1 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

Status: PROVISIONAL

Source sequence(s)

DN534407, NKLS02000014

UniProtKB/TrEMBL

E1BDL7

Related

ENSBTAP00000023938.6, ENSBTAT00000023938.7

Conserved Domains (7) summary

smart00228
Location:675 → 743

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:595 → 670

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04439
Location:382 → 462

DEP_1_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...

cd04440
Location:474 → 566

DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...

cd01224
Location:218 → 364

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

pfam00169
Location:248 → 356

PH; PH domain

pfam00621
Location:27 → 213

RhoGEF; RhoGEF domain