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    Ppp1r10 protein phosphatase 1, regulatory subunit 10 [ Mus musculus (house mouse) ]

    Gene ID: 52040, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Ppp1r10provided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 10provided by MGI
    Primary source
    MGI:MGI:1289273
    See related
    Ensembl:ENSMUSG00000039220 AllianceGenome:MGI:1289273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fb19; Cat53; Pnuts; D17Ertd808e; 2610025H06Rik
    Summary
    Predicted to enable protein phosphatase 1 binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of cardiac muscle cell apoptotic process; negative regulation of mitotic DNA damage checkpoint; and positive regulation of telomere maintenance. Located in chromatin. Part of PTW/PP1 phosphatase complex. Is expressed in central nervous system; early conceptus; oocyte; and retina. Orthologous to human PPP1R10 (protein phosphatase 1 regulatory subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 26.6), thymus adult (RPKM 16.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp1r10 in Genome Data Viewer
    Location:
    17 B1; 17 18.77 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36227404..36243175)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35916512..35932283)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10949 Neighboring gene predicted gene 16279 Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene STARR-seq mESC enhancer starr_42481 Neighboring gene microRNA 1894 Neighboring gene STARR-seq mESC enhancer starr_42482 Neighboring gene STARR-positive B cell enhancer ABC_E11644 Neighboring gene STARR-seq mESC enhancer starr_42484 Neighboring gene ring-box 1, pseudogene Neighboring gene protein phosphatase 1, regulatory subunit 10 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cells. De Leon G, et al. Int J Oncol, 2010 May. PMID 20372802, Free PMC Article
    2. PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1. Rose M, et al. Mol Cell Neurosci, 2008 Apr. PMID 18325784
    3. TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs. Kim H, et al. Nat Struct Mol Biol, 2009 Apr. PMID 19287395
    4. Identification and characterization of a novel human PP1 phosphatase complex. Lee JH, et al. J Biol Chem, 2010 Aug 6. PMID 20516061, Free PMC Article
    5. Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Eisenhardt AE, et al. Oncotarget, 2016 May 3. PMID 27034005, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Transgenic (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase 1 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitotic DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of PTW/PP1 phosphatase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PTW/PP1 phosphatase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 1 regulatory subunit 10
    Names
    HLA-C adjacent transcript 53
    MHC class I region proline-rich protein CAT53
    protein phosphatase I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163818.1 → NP_001157290.1  serine/threonine-protein phosphatase 1 regulatory subunit 10

      See identical proteins and their annotated locations for NP_001157290.1

      Status: VALIDATED

      Source sequence(s)
      AW456628, BC052059
      Consensus CDS
      CCDS50098.1
      UniProtKB/Swiss-Prot
      B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8
      UniProtKB/TrEMBL
      Q3ULI5
      Related
      ENSMUSP00000084460.7, ENSMUST00000087210.7
      Conserved Domains (2) summary
      pfam18044
      Location:858 → 880
      zf-CCCH_4; CCCH-type zinc finger
      cl00146
      Location:102 → 146
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    2. NM_001357740.1 → NP_001344669.1  serine/threonine-protein phosphatase 1 regulatory subunit 10

      Status: VALIDATED

      Source sequence(s)
      AJ504718, CR974451
      Consensus CDS
      CCDS50098.1
      UniProtKB/Swiss-Prot
      B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8
      UniProtKB/TrEMBL
      Q3ULI5
      Conserved Domains (2) summary
      pfam18044
      Location:858 → 880
      zf-CCCH_4; CCCH-type zinc finger
      cl00146
      Location:102 → 146
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    3. NM_001403564.1 → NP_001390493.1  serine/threonine-protein phosphatase 1 regulatory subunit 10

      Status: VALIDATED

      Source sequence(s)
      CR974451
      UniProtKB/Swiss-Prot
      B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8
      UniProtKB/TrEMBL
      Q3ULI5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      36227404..36243175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160685.1 → XP_036016578.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

      UniProtKB/Swiss-Prot
      B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8
      UniProtKB/TrEMBL
      Q3ULI5
      Conserved Domains (2) summary
      pfam18044
      Location:858 → 880
      zf-CCCH_4; CCCH-type zinc finger
      cl00146
      Location:102 → 146
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    2. XM_006524617.2 → XP_006524680.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

      See identical proteins and their annotated locations for XP_006524680.1

      UniProtKB/Swiss-Prot
      B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8
      UniProtKB/TrEMBL
      Q3ULI5
      Related
      ENSMUSP00000084461.3, ENSMUST00000087211.9
      Conserved Domains (2) summary
      pfam18044
      Location:858 → 880
      zf-CCCH_4; CCCH-type zinc finger
      cl00146
      Location:102 → 146
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    3. XM_006524619.3 → XP_006524682.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

      See identical proteins and their annotated locations for XP_006524682.1

      UniProtKB/Swiss-Prot
      B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8
      UniProtKB/TrEMBL
      Q3ULI5
      Conserved Domains (2) summary
      pfam18044
      Location:858 → 880
      zf-CCCH_4; CCCH-type zinc finger
      cl00146
      Location:102 → 146
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    4. XM_030249898.2 → XP_030105758.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

      UniProtKB/Swiss-Prot
      B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8
      UniProtKB/TrEMBL
      Q3ULI5
      Conserved Domains (2) summary
      pfam18044
      Location:858 → 880
      zf-CCCH_4; CCCH-type zinc finger
      cl00146
      Location:102 → 146
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175934.3: Suppressed sequence

      Description
      NM_175934.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80W00.1 GenPept UniProtKB/Swiss-Prot:Q80W00

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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