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    SYK spleen associated tyrosine kinase [ Bos taurus (domestic cattle) ]

    Gene ID: 515515, updated on 4-Oct-2024

    Summary

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    Official Symbol
    SYKprovided by VGNC
    Official Full Name
    spleen associated tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:35513
    See related
    BGD:BT18159; Ensembl:ENSBTAG00000004767
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SYK in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (86975440..87083485, complement)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene AU RNA binding methylglutaconyl-CoA hydratase Neighboring gene dnaJ homolog subfamily A member 2-like Neighboring gene uncharacterized LOC132345995 Neighboring gene DIRAS family GTPase 2 Neighboring gene U11 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of Syk expression in bovine lymphoma and persistent lymphocytosis induced by bovine leukemia virus. Murakami H, et al. J Vet Med Sci, 2011 Jan. PMID 20736517
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data suggest that Syk mRNA expression dynamics is closely related to bovine leukemia virus-induced disease.
      Title: Analysis of Syk expression in bovine lymphoma and persistent lymphocytosis induced by bovine leukemia virus.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC127145

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in macrophage activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neutrophil activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of alpha-beta T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of platelet aggregation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extrinsic component of cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase SYK
    Names
    spleen tyrosine kinase
    NP_001032542.1
    XP_005210492.1
    XP_059745061.1
    XP_059745062.1
    XP_059745063.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037465.2 → NP_001032542.1  tyrosine-protein kinase SYK

      See identical proteins and their annotated locations for NP_001032542.1

      Status: PROVISIONAL

      Source sequence(s)
      BC108086
      UniProtKB/TrEMBL
      Q32PK0
      Related
      ENSBTAP00000064678.1, ENSBTAT00000086544.2
      Conserved Domains (4) summary
      cd05116
      Location:345 → 601
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:8 → 111
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:344 → 596
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:159 → 256
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      86975440..87083485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005210435.5 → XP_005210492.1  tyrosine-protein kinase SYK isoform X1

      See identical proteins and their annotated locations for XP_005210492.1

      UniProtKB/TrEMBL
      A0A3Q1MHG9
      Related
      ENSBTAP00000006260.4, ENSBTAT00000006260.5
      Conserved Domains (4) summary
      cd05116
      Location:368 → 624
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:8 → 111
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:367 → 619
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:159 → 256
      SH2; Src homology 2 (SH2) domain

    2. XM_059889078.1 → XP_059745061.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MHG9

    3. XM_059889080.1 → XP_059745063.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MHG9

    4. XM_059889079.1 → XP_059745062.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MHG9
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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