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    CINP cyclin dependent kinase 2 interacting protein [ Homo sapiens (human) ]

    Gene ID: 51550, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CINPprovided by HGNC
    Official Full Name
    cyclin dependent kinase 2 interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:23789
    See related
    Ensembl:ENSG00000100865 MIM:613362; AllianceGenome:HGNC:23789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
    Expression
    Ubiquitous expression in testis (RPKM 6.8), brain (RPKM 6.4) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See CINP in Genome Data Viewer
    Location:
    14q32.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102348282..102362890, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (96583876..96598485, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102814619..102829227, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9070 Neighboring gene tRNA-Ile (anticodon AAT) 5-4 Neighboring gene zinc finger protein 839 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6115 Neighboring gene uncharacterized LOC124903389 Neighboring gene uncharacterized LOC124903440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9072 Neighboring gene tectonin beta-propeller repeat containing 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:102877147-102878136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6116 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102906165-102906672 Neighboring gene RNA, U6 small nuclear 244, pseudogene Neighboring gene ankyrin repeat domain 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Paulsen RD, et al. Mol Cell, 2009 Jul 31. PMID 19647519, Free PMC Article
    2. Modification of gene expression by melatonin in UVB-irradiated HaCaT keratinocyte cell lines using a cDNA microarray. Cho JW, et al. Oncol Rep, 2007 Mar. PMID 17273735
    3. CINP is a novel cofactor of KLF5 required for its role in the promotion of cell proliferation, survival and tumor growth. Wu Q, et al. Int J Cancer, 2019 Feb 1. PMID 30289973, Free PMC Article
    4. Functional genomic screens identify CINP as a genome maintenance protein. Lovejoy CA, et al. Proc Natl Acad Sci U S A, 2009 Nov 17. PMID 19889979, Free PMC Article
    5. CEP152 is a genome maintenance protein disrupted in Seckel syndrome. Kalay E, et al. Nat Genet, 2011 Jan. PMID 21131973, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing CINP had the most potent inhibitory effect on cell growth in KLF5-expressing cells but did not affect parental TSU-Pr1 cells. Further analyses not only confirmed the physical interaction between KLF5 and CINP, also demonstrated that knockdown of CINP attenuated the effects of KLF5 on cell cycle progression, apoptosis and tumorigenesis.
      Title: CINP is a novel cofactor of KLF5 required for its role in the promotion of cell proliferation, survival and tumor growth.
    2. NS5B delays cells in S phase through interaction with CINP and relocalization of the protein from the nucleus to the cytoplasm
      Title: Hepatitis C virus NS5B protein delays s phase progression in human hepatocyte-derived cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP).
    3. CINP interacts with ATR-interacting protein and regulates ATR-dependent signaling, resistance to replication stress, and G2 checkpoint integrity.
      Title: Functional genomic screens identify CINP as a genome maintenance protein.
    4. CINP is part of the Cdc7-dependent mechanism of origin firing and a functional and physical link between Cdk2 and Cdc7 complexes at the origins
      Title: A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC849

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables preribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 2-interacting protein
    Names
    CDK2-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320046.2 → NP_001306975.1  cyclin-dependent kinase 2-interacting protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL137229, DA167716
      Consensus CDS
      CCDS53915.1
      UniProtKB/TrEMBL
      H0YKY0
      Related
      ENSP00000442377.2, ENST00000541568.6

    2. NM_032630.3 → NP_116019.1  cyclin-dependent kinase 2-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_116019.1

      Status: REVIEWED

      Source sequence(s)
      BC000600, DA351468, EL951117
      Consensus CDS
      CCDS9972.1
      UniProtKB/Swiss-Prot
      F5H7P3, F5H8A7, Q9BW66, Q9NPF9
      UniProtKB/TrEMBL
      Q86TU0
      Related
      ENSP00000216756.6, ENST00000216756.11

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      102348282..102362890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      96583876..96598485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001177611.1: Suppressed sequence

      Description
      NM_001177611.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_001177612.1: Suppressed sequence

      Description
      NM_001177612.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BW66.1 GenPept UniProtKB/Swiss-Prot:Q9BW66

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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