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    UCHL1 ubiquitin C-terminal hydrolase L1 [ Bos taurus (domestic cattle) ]

    Gene ID: 514394, updated on 4-Oct-2024

    Summary

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    Official Symbol
    UCHL1provided by VGNC
    Official Full Name
    ubiquitin C-terminal hydrolase L1provided by VGNC
    Primary source
    VGNC:VGNC:36631
    See related
    BGD:BT12047; Ensembl:ENSBTAG00000005078
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See UCHL1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (60147577..60159280)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene amyloid beta precursor protein binding family B member 2 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene uncharacterized LOC132345503 Neighboring gene uncharacterized LOC132345504 Neighboring gene LIM and calponin homology domains 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of ubiquitin C-terminal hydrolase-L1 in antipolyspermy defense of mammalian oocytes. Susor A, et al. Biol Reprod, 2010 Jun. PMID 20164442
    2. 'Neuron-specific' protein gene product 9.5 (PGP 9.5) is also expressed in glioma cell lines and its expression depends on cellular growth state. Giambanco I, et al. FEBS Lett, 1991 Sep 23. PMID 1833240
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC133697

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase isozyme L1
    Names
    PGP 9.5
    PGP9.5
    UCH-L1
    neuron cytoplasmic protein 9.5
    ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
    ubiquitin carboxyl-terminal hydrolase L1
    ubiquitin thioesterase L1
    NP_001039637.1
    XP_005207929.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046172.2 → NP_001039637.1  ubiquitin carboxyl-terminal hydrolase isozyme L1

      See identical proteins and their annotated locations for NP_001039637.1

      Status: PROVISIONAL

      Source sequence(s)
      BC111330
      UniProtKB/Swiss-Prot
      P23356, Q2NKZ2
      UniProtKB/TrEMBL
      A0AAF6ZGE9
      Related
      ENSBTAP00000044075.2, ENSBTAT00000046823.3
      Conserved Domains (1) summary
      cd09616
      Location:5 → 248
      Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      60147577..60159280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005207872.5 → XP_005207929.1  ubiquitin carboxyl-terminal hydrolase isozyme L1 isoform X1

      See identical proteins and their annotated locations for XP_005207929.1

      UniProtKB/TrEMBL
      A0AAF6ZGE9
      Related
      ENSBTAP00000063885.2, ENSBTAT00000066434.2
      Conserved Domains (1) summary
      cd09616
      Location:5 → 219
      Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23356.2 GenPept UniProtKB/Swiss-Prot:P23356

    Gene LinkOut

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