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    PARL presenilin associated rhomboid like [ Bos taurus (domestic cattle) ]

    Gene ID: 514191, updated on 10-Oct-2024

    Summary

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    Official Symbol
    PARLprovided by VGNC
    Official Full Name
    presenilin associated rhomboid likeprovided by VGNC
    Primary source
    VGNC:VGNC:53595
    See related
    Ensembl:ENSBTAG00000014460
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PSARL
    Orthologs
    human mouse all
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    Genomic context

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    See PARL in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (83246190..83301297)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene glycine cleavage system H protein, mitochondrial-like Neighboring gene cytochrome P450 2J2-like Neighboring gene small ribosomal subunit protein uS15-like Neighboring gene MAP6 domain containing 1 Neighboring gene YEATS domain containing 2 Neighboring gene large ribosomal subunit protein eL30-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC137354

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    presenilin-associated rhomboid-like protein, mitochondrial
    Names
    mitochondrial intramembrane cleaving protease PARL
    presenilin associated, rhomboid-like preproprotein
    presenilins-associated rhomboid-like protein, mitochondrial
    NP_001015596.1
    XP_024840318.1
    XP_059737166.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015596.1 → NP_001015596.1  presenilin-associated rhomboid-like protein, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001015596.1

      Status: PROVISIONAL

      Source sequence(s)
      BT020676
      UniProtKB/Swiss-Prot
      A1L5A2, Q0V8C8, Q2KHV4, Q5EA93
      Related
      ENSBTAP00000019227.6, ENSBTAT00000019227.7
      Conserved Domains (1) summary
      pfam01694
      Location:207 → 348
      Rhomboid; Rhomboid family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      83246190..83301297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059881183.1 → XP_059737166.1  presenilin-associated rhomboid-like protein, mitochondrial isoform X1

    2. XM_024984550.2 → XP_024840318.1  presenilin-associated rhomboid-like protein, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl21536
      Location:207 → 274
      Rhomboid; Rhomboid family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2KHV4.1 GenPept UniProtKB/Swiss-Prot:Q2KHV4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials