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    MYOF myoferlin [ Bos taurus (domestic cattle) ]

    Gene ID: 513597, updated on 4-Oct-2024

    Summary

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    Official Symbol
    MYOFprovided by VGNC
    Official Full Name
    myoferlinprovided by VGNC
    Primary source
    VGNC:VGNC:31836
    See related
    BGD:BT21539; Ensembl:ENSBTAG00000016918
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    FER1L3
    Orthologs
    human mouse all
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    Genomic context

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    See MYOF in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    57
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (14623106..14803396, complement)

    Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 26 subfamily C member 1 Neighboring gene cytochrome P450 family 26 subfamily A member 1 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene centrosomal protein 55 Neighboring gene free fatty acid receptor 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T-tubule organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in membrane fusion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in plasma membrane repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myoferlin
    Names
    fer-1-like 3, myoferlin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193212.3 → NP_001180141.2  myoferlin

      Status: PROVISIONAL

      Source sequence(s)
      CB419566, EV684499, NKLS02000026
      UniProtKB/TrEMBL
      F1N3I4
      Conserved Domains (11) summary
      cd04011
      Location:196 → 305
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1139 → 1272
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:359 → 535
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1554 → 1677
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:5 → 135
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1790 → 1921
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:927 → 983
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:769 → 841
      FerB; FerB (NUC096) domain
      pfam08151
      Location:303 → 353
      FerI; FerI (NUC094) domain
      pfam08165
      Location:680 → 737
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1937 → 2056
      Ferlin_C; Ferlin C-terminus

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      14623106..14803396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024985591.2 → XP_024841359.1  myoferlin isoform X4

      UniProtKB/TrEMBL
      F1N3I4
      Conserved Domains (11) summary
      cd04011
      Location:195 → 304
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1125 → 1258
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:358 → 521
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1540 → 1663
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:5 → 135
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1776 → 1907
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:913 → 969
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:755 → 827
      FerB; FerB (NUC096) domain
      pfam08151
      Location:302 → 352
      FerI; FerI (NUC094) domain
      pfam08165
      Location:666 → 723
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1923 → 2042
      Ferlin_C; Ferlin C-terminus

    2. XM_024985588.2 → XP_024841356.1  myoferlin isoform X2

      UniProtKB/TrEMBL
      F1N3I4
      Conserved Domains (11) summary
      cd04011
      Location:195 → 304
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1125 → 1258
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:358 → 521
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1559 → 1682
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:5 → 135
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1795 → 1926
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:913 → 969
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:755 → 827
      FerB; FerB (NUC096) domain
      pfam08151
      Location:302 → 352
      FerI; FerI (NUC094) domain
      pfam08165
      Location:666 → 723
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1942 → 2061
      Ferlin_C; Ferlin C-terminus

    3. XM_024985589.2 → XP_024841357.1  myoferlin isoform X3

      UniProtKB/TrEMBL
      F1N3I4
      Related
      ENSBTAP00000038769.5, ENSBTAT00000038965.6
      Conserved Domains (11) summary
      cd04011
      Location:195 → 304
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1138 → 1271
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:358 → 534
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1553 → 1676
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:5 → 135
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1789 → 1920
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:926 → 982
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:768 → 840
      FerB; FerB (NUC096) domain
      pfam08151
      Location:302 → 352
      FerI; FerI (NUC094) domain
      pfam08165
      Location:679 → 736
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1936 → 2055
      Ferlin_C; Ferlin C-terminus

    4. XM_024985587.2 → XP_024841355.1  myoferlin isoform X1

      UniProtKB/TrEMBL
      F1N3I4
      Conserved Domains (11) summary
      cd04011
      Location:195 → 304
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1138 → 1271
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:358 → 534
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1572 → 1695
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:5 → 135
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1808 → 1939
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:926 → 982
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:768 → 840
      FerB; FerB (NUC096) domain
      pfam08151
      Location:302 → 352
      FerI; FerI (NUC094) domain
      pfam08165
      Location:679 → 736
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1955 → 2074
      Ferlin_C; Ferlin C-terminus

    5. XM_005225523.5 → XP_005225580.2  myoferlin isoform X5

      UniProtKB/TrEMBL
      F1N3I4
      Conserved Domains (9) summary
      cd04011
      Location:195 → 304
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1138 → 1271
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:358 → 534
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1572 → 1695
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:5 → 135
      C2A_Ferlin; C2 domain first repeat in Ferlin
      smart00693
      Location:926 → 982
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:768 → 840
      FerB; FerB (NUC096) domain
      pfam08151
      Location:302 → 352
      FerI; FerI (NUC094) domain
      pfam08165
      Location:679 → 736
      FerA; FerA (NUC095) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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