U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    MARS1 methionyl-tRNA synthetase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 512531, updated on 4-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MARS1provided by VGNC
    Official Full Name
    methionyl-tRNA synthetase 1provided by VGNC
    Primary source
    VGNC:VGNC:31250
    See related
    BGD:BT25809; Ensembl:ENSBTAG00000018405
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    MARS
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MARS1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (55960457..55979225, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene methyl-CpG binding domain protein 6 Neighboring gene DDIT3 upstream open reading frame protein Neighboring gene DNA damage inducible transcript 3 Neighboring gene microRNA mir-2430 Neighboring gene Rho GTPase activating protein 9 Neighboring gene GLI family zinc finger 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC134096

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methionine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methionyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    methionine--tRNA ligase, cytoplasmic
    Names
    metRS
    methionine-tRNA synthetase
    methionyl-tRNA synthetase, cytoplasmic
    NP_001033180.1
    XP_024847411.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038091.2 → NP_001033180.1  methionine--tRNA ligase, cytoplasmic

      Status: PROVISIONAL

      Source sequence(s)
      BC111362
      UniProtKB/Swiss-Prot
      Q2T9L8
      UniProtKB/TrEMBL
      A0A3Q1LLF2
      Related
      ENSBTAP00000057583.2, ENSBTAT00000080505.2
      Conserved Domains (7) summary
      cd07957
      Location:642 → 771
      Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases
      cd00814
      Location:265 → 633
      MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
      cd10307
      Location:77 → 179
      GST_C_MetRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Methionyl-tRNA synthetase from higher eukaryotes
      COG0625
      Location:47 → 189
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      PRK12268
      Location:264 → 819
      PRK12268; methionyl-tRNA synthetase; Reviewed
      cd00939
      Location:843 → 887
      MetRS_RNA; MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is ...
      cl00388
      Location:27 → 68
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      55960457..55979225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024991643.2 → XP_024847411.1  methionine--tRNA ligase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LLF2, F1MDW1
      Related
      ENSBTAP00000024487.4, ENSBTAT00000024487.5
      Conserved Domains (2) summary
      cd10307
      Location:77 → 179
      GST_C_MetRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Methionyl-tRNA synthetase from higher eukaryotes
      cl26127
      Location:251 → 882
      PRK12267; methionyl-tRNA synthetase; Reviewed
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2T9L8.1 GenPept UniProtKB/Swiss-Prot:Q2T9L8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials