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    GCLC glutamate-cysteine ligase catalytic subunit [ Bos taurus (domestic cattle) ]

    Gene ID: 512468, updated on 10-Oct-2024

    Summary

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    Official Symbol
    GCLCprovided by VGNC
    Official Full Name
    glutamate-cysteine ligase catalytic subunitprovided by VGNC
    Primary source
    VGNC:VGNC:29289
    See related
    Ensembl:ENSBTAG00000015571
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See GCLC in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (6982221..7026848)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 1 Neighboring gene kelch like family member 31 Neighboring gene major histocompatibility complex, class II, DY alpha Neighboring gene MHC class II antigen DS beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glutathione content and expression of proteins involved with glutathione metabolism differs in longissimus dorsi, subcutaneous adipose, and liver tissues of finished vs. growing beef steers. Huang J, et al. J Anim Sci, 2018 Dec 3. PMID 30204884, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables glutamate-cysteine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of glutamate-cysteine ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate--cysteine ligase catalytic subunit
    NP_001077143.1
    XP_005223293.1
    XP_005223294.1
    XP_059736279.1
    XP_059736280.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083674.1 → NP_001077143.1  glutamate--cysteine ligase catalytic subunit

      See identical proteins and their annotated locations for NP_001077143.1

      Status: PROVISIONAL

      Source sequence(s)
      AY957499
      UniProtKB/TrEMBL
      A0A3Q1LU91, Q32S38
      Related
      ENSBTAP00000045984.1, ENSBTAT00000049040.3
      Conserved Domains (1) summary
      pfam03074
      Location:219 → 576
      GCS; Glutamate-cysteine ligase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      6982221..7026848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005223236.5 → XP_005223293.1  glutamate--cysteine ligase catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MN33, A0AAA9U023
      Related
      ENSBTAP00000070904.1, ENSBTAT00000081594.2
      Conserved Domains (2) summary
      pfam03074
      Location:236 → 609
      GCS; Glutamate-cysteine ligase
      cl28253
      Location:22 → 76
      RpsA; Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]

    2. XM_005223237.5 → XP_005223294.1  glutamate--cysteine ligase catalytic subunit isoform X2

      UniProtKB/TrEMBL
      A0AAA9U023
      Related
      ENSBTAP00000102382.1, ENSBTAT00000118809.1
      Conserved Domains (2) summary
      pfam03074
      Location:236 → 608
      GCS; Glutamate-cysteine ligase
      cl28253
      Location:22 → 76
      RpsA; Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]

    3. XM_059880297.1 → XP_059736280.1  glutamate--cysteine ligase catalytic subunit isoform X4

      UniProtKB/TrEMBL
      A0A3Q1LUC8
      Related
      ENSBTAP00000060729.1, ENSBTAT00000074624.2

    4. XM_059880296.1 → XP_059736279.1  glutamate--cysteine ligase catalytic subunit isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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