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    METTL1 methyltransferase 1, tRNA methylguanosine [ Bos taurus (domestic cattle) ]

    Gene ID: 511197, updated on 4-Oct-2024

    Summary

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    Official Symbol
    METTL1provided by VGNC
    Official Full Name
    methyltransferase 1, tRNA methylguanosineprovided by VGNC
    Primary source
    VGNC:VGNC:31400
    See related
    BGD:BT20318; Ensembl:ENSBTAG00000016908
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See METTL1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (55693557..55697177)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene Ts translation elongation factor, mitochondrial Neighboring gene EEF1A lysine methyltransferase 3 Neighboring gene cytochrome P450 family 27 subfamily B member 1 Neighboring gene membrane associated ring-CH-type finger 9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC134433

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables tRNA (guanine(46)-N7)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA (guanine-N7)-methylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of tRNA methyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tRNA (guanine-N(7)-)-methyltransferase
    Names
    mRNA (guanine-N(7)-)-methyltransferase
    methyltransferase like 1
    methyltransferase-like protein 1
    miRNA (guanine-N(7)-)-methyltransferase
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    NP_001039542.1
    XP_005206619.1
    XP_024847388.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046077.2 → NP_001039542.1  tRNA (guanine-N(7)-)-methyltransferase

      See identical proteins and their annotated locations for NP_001039542.1

      Status: PROVISIONAL

      Source sequence(s)
      BC110252
      UniProtKB/Swiss-Prot
      Q2YDF1
      UniProtKB/TrEMBL
      A0AAF6Z3Q7
      Related
      ENSBTAP00000022487.6, ENSBTAT00000022487.7
      Conserved Domains (1) summary
      pfam02390
      Location:78 → 255
      Methyltransf_4; Putative methyltransferase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      55693557..55697177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005206562.5 → XP_005206619.1  tRNA (guanine-N(7)-)-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0AAF6Z3Q7
      Conserved Domains (3) summary
      COG0220
      Location:17 → 312
      TrmB; tRNA G46 methylase TrmB [Translation, ribosomal structure and biogenesis]
      pfam02390
      Location:145 → 308
      Methyltransf_4; Putative methyltransferase
      pfam15692
      Location:47 → 74
      NKAP; NF-kappa-B-activating protein

    2. XM_024991620.2 → XP_024847388.1  tRNA (guanine-N(7)-)-methyltransferase isoform X2

      Conserved Domains (1) summary
      cl17173
      Location:145 → 274
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2YDF1.1 GenPept UniProtKB/Swiss-Prot:Q2YDF1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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